OBJECTIVE: To evaluate the role of the Gleason score of needle biopsies of the prostate in predicting the final pathological staging of patients with carcinoma of the prostate treated by radical prostatectomy. PATIENTS AND METHODS: The records of 466 patients with carcinoma of the prostate treated by radical prostatectomy were reviewed, comparing the Gleason scores of the core-needle biopsies with the Gleason score and final pathological staging of the surgical specimens. RESULTS: The biopsy grade was the same as that of the prostatectomy specimen in 54% of the patients. The most common discordance was the upgrading of well-differentiated tumours in 75% of the patients. When the biopsy grade was compared with the surgical pathological stage, 49% of low- and 82% of high-grade lesions in the biopsy had capsular penetration by tumour or locally advanced disease (Stage C and D1). CONCLUSION: Well-differentiated tumours on the biopsy core are not predictive of organ-confined disease, but a poorly differentiated lesion is a good indicator of extracapsular extension of the cancer.
OBJECTIVE: To evaluate the role of the Gleason score of needle biopsies of the prostate in predicting the final pathological staging of patients with carcinoma of the prostate treated by radical prostatectomy. PATIENTS AND METHODS: The records of 466 patients with carcinoma of the prostate treated by radical prostatectomy were reviewed, comparing the Gleason scores of the core-needle biopsies with the Gleason score and final pathological staging of the surgical specimens. RESULTS: The biopsy grade was the same as that of the prostatectomy specimen in 54% of the patients. The most common discordance was the upgrading of well-differentiated tumours in 75% of the patients. When the biopsy grade was compared with the surgical pathological stage, 49% of low- and 82% of high-grade lesions in the biopsy had capsular penetration by tumour or locally advanced disease (Stage C and D1). CONCLUSION: Well-differentiated tumours on the biopsy core are not predictive of organ-confined disease, but a poorly differentiated lesion is a good indicator of extracapsular extension of the cancer.
Authors: Anup Vora; Tim Large; Jenny Aronica; Sherod Haynes; Andrew Harbin; Daniel Marchalik; Hanaa Nissim; John Lynch; Gaurav Bandi; Kevin McGeagh; Keith Kowalczyk; Reza Ghasemian; Krishnan Venkatesan; Mohan Verghese; Jonathan Hwang Journal: Int Urol Nephrol Date: 2013-07-18 Impact factor: 2.370
Authors: M Kongnyuy; M M Siddiqui; A K George; A Muthigi; A Sidana; M Maruf; B Turkbey; P L Choyke; B J Wood; P A Pinto Journal: Prostate Cancer Prostatic Dis Date: 2017-04-25 Impact factor: 5.554
Authors: Marko Brock; Christian von Bodman; Jüri Palisaar; Wolfgang Becker; Philipp Martin-Seidel; Joachim Noldus Journal: Dtsch Arztebl Int Date: 2015-09-11 Impact factor: 5.594
Authors: Brian P Calio; Abhinav Sidana; Dordaneh Sugano; Sonia Gaur; Mahir Maruf; Amit L Jain; Maria J Merino; Peter L Choyke; Bradford J Wood; Peter A Pinto; Baris Turkbey Journal: J Urol Date: 2018-01-20 Impact factor: 7.450
Authors: Benedict J Kang; Minhong Jeun; Gun Hyuk Jang; Sang Hoon Song; In Gab Jeong; Choung-Soo Kim; Peter C Searson; Kwan Hyi Lee Journal: Int J Nanomedicine Date: 2015-10-19