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Literature DB >> 883817

2"-O-phosphorylation of gentamicin components by a Staphylococcus aureus strain carrying a plasmid.

A Martel, N Moreau, M L Capmau, C J Soussy, J Duval.

Abstract

A wild-type strain of Staphylococcus aureus that inactivates the 4,6-glycosidically linked deoxystreptamine aminoglycoside antibiotics by a plasmid-mediated process was found to harbor two enzymes: an acetyltransferase of the AAC(6') type and a new phosphotranferase specific to the gentamicin components. The target of this last enzyme is the 2''-hydroxyl function of these antibiotics, since one inactivated compound is 2''-(O)-phosphorylsisomicin.

Entities: Chemical Species

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Year: 1977 PMID： 883817 PMCID： PMC352148 DOI： 10.1128/AAC.12.1.26

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

1. Properties of the gentamicin acetyltransferase enzyme and application to the assay of aminoglycoside antibiotics.

Authors: J M Broughall; D S Reeves
Journal: Antimicrob Agents Chemother Date: 1975-08 Impact factor: 5.191

2. Purification by affinity chromatography of an enzyme involved in gentamicin inactivation.

Authors: F Le Goffic; N Moreau
Journal: FEBS Lett Date: 1973-02-01 Impact factor: 4.124

3. Mass spectral studies on aminocyclitol-aminoglycoside antibiotics.

Authors: P J Daniels; A K Mallams; J Weinstein; J J Wright; G W Milne
Journal: J Chem Soc Perkin 1 Date: 1976

4. A new rapid and powerful technique to obtain purified ribosomes.

Authors: F Le Goffic; B Baca; N Moreau
Journal: FEBS Lett Date: 1974-04-15 Impact factor: 4.124

5. [Resistance to aminosides induced by an isoenzyme, kanamycin acetyltransferase].

Authors: F Le Goffic; A Martel
Journal: Biochimie Date: 1974 Impact factor: 4.079

6. Enzymatic modification of aminoglycoside antibiotics: a new 6'-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.

Authors: M Haas; S Biddlecome; J Davies; C E Luce; P J Daniels
Journal: Antimicrob Agents Chemother Date: 1976-06 Impact factor: 5.191

7. Purification and properties of gentamicin acetyltransferase I.

Authors: J W Williams; D B Northrop
Journal: Biochemistry Date: 1976-01-13 Impact factor: 3.162

8. Gentamicin resistance in Staphylococcus aureus.

Authors: A Porthouse; D F Brown; R G Smith; T Rogers
Journal: Lancet Date: 1976-01-03 Impact factor: 79.321

9. New plasmid-mediated nucleotidylation of aminoglycoside antibiotics in Staphlococcus aureus.

Authors: F Le Goffic; A Martel; M L Capmau; B Baca; P Goebel; H Chardon; C J Soussy; J Duval; D H Bouanchaud
Journal: Antimicrob Agents Chemother Date: 1976-08 Impact factor: 5.191

10. [ANT(4')I: a new aminoglycoside nucleotidyltransferase found in "staphylococcus aureus" (author's transl)].

Authors: F Le Goffic; B Baca; C J Soussy; A Dublanchet; J Duval
Journal: Ann Microbiol (Paris) Date: 1976-04

21 in total

1. Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside (2'') phosphotransferase-ia reveals a rigid solution structure.

Authors: Shane J Caldwell; Albert M Berghuis
Journal: Antimicrob Agents Chemother Date: 2012-01-30 Impact factor: 5.191

Review 2. Antimicrobial resistance of Staphylococcus aureus: genetic basis.

Authors: B R Lyon; R Skurray
Journal: Microbiol Rev Date: 1987-03

3. Effect of aminoglycoside concentration on reaction rates of aminoglycoside-modifying enzymes.

Authors: G P Bongaerts; J S Vliegenthart
Journal: Antimicrob Agents Chemother Date: 1988-05 Impact factor: 5.191

4. Nucleotide sequence analysis of the gene specifying the bifunctional 6'-aminoglycoside acetyltransferase 2"-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activities.

Authors: J J Ferretti; K S Gilmore; P Courvalin
Journal: J Bacteriol Date: 1986-08 Impact factor: 3.490