Literature DB >> 2840015

Effect of aminoglycoside concentration on reaction rates of aminoglycoside-modifying enzymes.

G P Bongaerts1, J S Vliegenthart.   

Abstract

Reaction rates of several reference aminoglycoside-modifying enzymes were studied at various substrate concentrations. The resulting concentration-response curves showed wide variation in threshold concentration, in curve slope, in enzyme saturation, and in substrate inhibition. Together, the curves of a defined aminoglycoside panel yielded more specific information for each individual aminoglycoside-modifying enzyme tested than did conventional substrate profiles obtained at a single substrate concentration.

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Year:  1988        PMID： 2840015      PMCID： PMC172263          DOI： 10.1128/AAC.32.5.740

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Aminoglycoside-modifying enzymes.

Authors:  M J Haas; J E Dowding
Journal:  Methods Enzymol       Date:  1975       Impact factor: 1.600

2.  2"-O-phosphorylation of gentamicin components by a Staphylococcus aureus strain carrying a plasmid.

Authors:  A Martel; N Moreau; M L Capmau; C J Soussy; J Duval
Journal:  Antimicrob Agents Chemother       Date:  1977-07       Impact factor: 5.191

3.  Resistance of bacteria to the newer aminoglycoside antibiotics: an epidemiological and enzymatic study.

Authors:  M Devaud; F H Kayser; U Huber
Journal:  J Antibiot (Tokyo)       Date:  1977-08       Impact factor: 2.649

4.  Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor.

Authors:  R Benveniste; J Davies
Journal:  Biochemistry       Date:  1971-05-11       Impact factor: 3.162

5.  Plasmid-medicated aminoglycoside phosphotransferase of broad substrate range that phosphorylates amikacin.

Authors:  P Courvalin; J Davies
Journal:  Antimicrob Agents Chemother       Date:  1977-04       Impact factor: 5.191

6.  Enzymatic modification of aminoglycoside antibiotics: a new 6'-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.

Authors:  M Haas; S Biddlecome; J Davies; C E Luce; P J Daniels
Journal:  Antimicrob Agents Chemother       Date:  1976-06       Impact factor: 5.191

7.  Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.

Authors:  S Biddlecome; M Haas; J Davies; G H Miller; D F Rane; P J Daniels
Journal:  Antimicrob Agents Chemother       Date:  1976-06       Impact factor: 5.191

8.  Aminoglycoside phosphotransferase-II-mediated amikacin resistance in Escherichia coli.

Authors:  G P Bongaerts; G M Kaptijn
Journal:  Antimicrob Agents Chemother       Date:  1981-09       Impact factor: 5.191

9.  Transferrable resistance to tobramycin in Klebsiella pneumoniae and Enterobacter cloacae associated with enzymatic acetylation of tobramycin.

Authors:  B H Minshew; R K Holmes; J P Sanford; C R Baxter
Journal:  Antimicrob Agents Chemother       Date:  1974-10       Impact factor: 5.191

10.  New plasmid-mediated aminoglycoside adenylyltransferase of broad substrate range that adenylylates amikacin.

Authors:  R G Coombe; A M George
Journal:  Antimicrob Agents Chemother       Date:  1981-07       Impact factor: 5.191
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  7 in total

1.  Nucleotide sequence of the aacC3 gene, a gentamicin resistance determinant encoding aminoglycoside-(3)-N-acetyltransferase III expressed in Pseudomonas aeruginosa but not in Escherichia coli.

Authors:  J S Vliegenthart; P A Ketelaar-van Gaalen; J A van de Klundert
Journal:  Antimicrob Agents Chemother       Date:  1991-05       Impact factor: 5.191

2.  Nucleotide sequence of the aacC2 gene, a gentamicin resistance determinant involved in a hospital epidemic of multiply resistant members of the family Enterobacteriaceae.

Authors:  J S Vliegenthart; P A Ketelaar-van Gaalen; J A van de Klundert
Journal:  Antimicrob Agents Chemother       Date:  1989-08       Impact factor: 5.191

3.  Overproduction of 3'-aminoglycoside phosphotransferase type I confers resistance to tobramycin in Escherichia coli.

Authors:  R Menard; C Molinas; M Arthur; J Duval; P Courvalin; R Leclercq
Journal:  Antimicrob Agents Chemother       Date:  1993-01       Impact factor: 5.191

4.  Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase.

Authors:  Sophie Magnet; Terry-Ann Smith; Renjian Zheng; Patrice Nordmann; John S Blanchard
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

5.  Different aminoglycoside-resistant phenotypes in a rabbit Staphylococcus aureus endocarditis infection model.

Authors:  N Asseray; J Caillon; N Roux; C Jacqueline; R Bismuth; M F Kergueris; G Potel; D Bugnon
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

6.  Aminoglycoside resistance in Mycobacterium kansasii, Mycobacterium avium-M. intracellulare, and Mycobacterium fortuitum: are aminoglycoside-modifying enzymes responsible?

Authors:  I I Ho; C Y Chan; A F Cheng
Journal:  Antimicrob Agents Chemother       Date:  2000-01       Impact factor: 5.191

7.  Structuring evolution: biochemical networks and metabolic diversification in birds.

Authors:  Erin S Morrison; Alexander V Badyaev
Journal:  BMC Evol Biol       Date:  2016-08-25       Impact factor: 3.260
  7 in total

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