Literature DB >> 984767

New plasmid-mediated nucleotidylation of aminoglycoside antibiotics in Staphlococcus aureus.

F Le Goffic, A Martel, M L Capmau, B Baca, P Goebel, H Chardon, C J Soussy, J Duval, D H Bouanchaud.   

Abstract

A wild-type strain of Staphylococcus aureus, which inactivates a wide variety of aminoglycosides (except the gentamicin components), has been found to harbor a plasmid (RAp01) that mediates the biosynthesis of a nucleotidyltransferase. This enzyme modifies the 4'-hydroxy function of these antibiotics. The plasmid has been studied, the enzyme responsible for this resistance pattern has been isolated by affinity chromatography, and its kinetics and physicochemistry have been characterized. The target of this enzyme has also been located by demonstrating the structure of one inactivated compound, 4'-(O)-adenylyltobramycin.

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Year:  1976        PMID： 984767      PMCID： PMC429732          DOI： 10.1128/AAC.10.2.258

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Purification by affinity chromatography of an enzyme involved in gentamicin inactivation.

Authors:  F Le Goffic; N Moreau
Journal:  FEBS Lett       Date:  1973-02-01       Impact factor: 4.124

2.  [Purification by affinity chromatography of an acetyltransferase and phosphotransferase inactivating aminosidic antibiotics].

Authors:  F Le Goffic; N Moreau; M Chevereau
Journal:  Biochimie       Date:  1973       Impact factor: 4.079

Review 3.  Mechanisms of antibiotic resistance in bacteria.

Authors:  R Benveniste; J Davies
Journal:  Annu Rev Biochem       Date:  1973       Impact factor: 23.643

4.  3-N enzymatic acetylation of gentamicin, tobramycin, and kanamycin by Escherichia coli carrying an R factor.

Authors:  F Le Goffic; A Martel; J Witchitz
Journal:  Antimicrob Agents Chemother       Date:  1974-12       Impact factor: 5.191

5.  Isolation and characterization of lividomycin A inactivated by Pseudomonas aeruginosa and Escherichia coli carrying R factor.

Authors:  S Kondo; H Yamamoto; H Naganawa; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1972-08       Impact factor: 2.649

6.  Elimination by ethidium bromide of antibiotic resistance in enterobacteria and staphylococci.

Authors:  D H Bouanchaud; M R Scavizzi; Y A Chabbert
Journal:  J Gen Microbiol       Date:  1968-12

7.  Inactivation and phosphorylation of kanamycin by drug-resistant Staphylococcus aureus.

Authors:  O Doi; M Miyamoto; N Tanaka; H Umezawa
Journal:  Appl Microbiol       Date:  1968-09

8.  The problems of drug-resistant pathogenic bacteria. Extrachromosomal nature of drug resistance in Staphylococcus aureus.

Authors:  R P Novick; D Bouanchaud
Journal:  Ann N Y Acad Sci       Date:  1971-06-11       Impact factor: 5.691

9.  A gentamycin resistance plasmid in Staphylococcus aureus.

Authors:  C J Soussy; D H Bouanchaud; J Fouace; A Dublanchet; J Duval
Journal:  Ann Microbiol (Paris)       Date:  1975 Jul-Aug

10.  Lividomycin resistance in staphylococci by enzymatic phosphorylation.

Authors:  F Kobayashi; T Koshi; J Eda; Y Yoshimura; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1973-07       Impact factor: 5.191
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  21 in total

1.  Self-Resistance during Muraymycin Biosynthesis: a Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order.

Authors:  Zheng Cui; Xia-Chang Wang; Xiaodong Liu; Anke Lemke; Stefan Koppermann; Christian Ducho; Jürgen Rohr; Jon S Thorson; Steven G Van Lanen
Journal:  Antimicrob Agents Chemother       Date:  2018-06-26       Impact factor: 5.191

2.  2"-O-phosphorylation of gentamicin components by a Staphylococcus aureus strain carrying a plasmid.

Authors:  A Martel; N Moreau; M L Capmau; C J Soussy; J Duval
Journal:  Antimicrob Agents Chemother       Date:  1977-07       Impact factor: 5.191

3.  Occurrence of 4'-O-aminoglycoside-nucleotidyltransferase in clinical strains of Enterobacteriaceae.

Authors:  M Kettner; T Macicková; V Krcméry
Journal:  Infection       Date:  1989 Mar-Apr       Impact factor: 3.553

Review 4.  Antimicrobial resistance of Staphylococcus aureus: genetic basis.

Authors:  B R Lyon; R Skurray
Journal:  Microbiol Rev       Date:  1987-03

5.  Plasmid-medicated aminoglycoside phosphotransferase of broad substrate range that phosphorylates amikacin.

Authors:  P Courvalin; J Davies
Journal:  Antimicrob Agents Chemother       Date:  1977-04       Impact factor: 5.191

6.  Correlation of antibiotic resistance with Vmax/Km ratio of enzymatic modification of aminoglycosides by kanamycin acetyltransferase.

Authors:  K Radika; D B Northrop
Journal:  Antimicrob Agents Chemother       Date:  1984-04       Impact factor: 5.191

7.  Comparison of in vitro activity of Sch 21420, a gentamicin B derivative, with those of amikacin, gentamicin, netilmicin, sisomicin, and tobramycin.

Authors:  C Thornsberry; A L Barry; R N Jones; C N Baker; R E Badal; R R Packer
Journal:  Antimicrob Agents Chemother       Date:  1980-08       Impact factor: 5.191

8.  In vitro susceptibility patterns of methicillin-resistant and-susceptible Staphylococcus auerues strains in a population of parenteral drug abusers from 1972 to 1981.

Authors:  N Markowitz; D J Pohlod; L D Saravolatz; E L Quinn
Journal:  Antimicrob Agents Chemother       Date:  1983-03       Impact factor: 5.191

9.  Decreased susceptibility to 4'-deoxy-6'-N-methylamikacin (BB-K311) conferred by a mutant plasmid in Escherichia coli.

Authors:  M H Perlin; S A Lerner
Journal:  Antimicrob Agents Chemother       Date:  1982-07       Impact factor: 5.191

10.  Metabolite profiling uncovers plasmid-induced cobalt limitation under methylotrophic growth conditions.

Authors:  Patrick Kiefer; Markus Buchhaupt; Philipp Christen; Björn Kaup; Jens Schrader; Julia A Vorholt
Journal:  PLoS One       Date:  2009-11-13       Impact factor: 3.240
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