Literature DB >> 820249

Enzymatic modification of aminoglycoside antibiotics: a new 6'-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.

M Haas, S Biddlecome, J Davies, C E Luce, P J Daniels.   

Abstract

We describe an aminoglycoside 6'-N-acetyltransferase, isolated from Pseudomonas aeruginosa, that exhibits a novel substrate profile characterized by markedly reduced activity towards butirosin and amikacin.

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Year:  1976        PMID： 820249      PMCID： PMC429655          DOI： 10.1128/AAC.9.6.945

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

1.  Aminoglycoside-modifying enzymes.

Authors:  M J Haas; J E Dowding
Journal:  Methods Enzymol       Date:  1975       Impact factor: 1.600

2.  [Resistance to aminosides induced by an isoenzyme, kanamycin acetyltransferase].

Authors:  F Le Goffic; A Martel
Journal:  Biochimie       Date:  1974       Impact factor: 4.079

3.  The structure of sisomicin, a novel unsaturated aminocyclitol antibiotic from Micromonospora inyoensis.

Authors:  H Reimann; D J Cooper; A K Mallams; R S Jaret; A Yehaskel; M Kugelman; H F Vernay; D Schumacher
Journal:  J Org Chem       Date:  1974-05-31       Impact factor: 4.354

4.  Utilization of carbon and nitrogen sources by Streptomyces kanamyceticus for kanamycin production.

Authors:  K Basak; S K Majumdar
Journal:  Antimicrob Agents Chemother       Date:  1973-07       Impact factor: 5.191

5.  Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor.

Authors:  R Benveniste; J Davies
Journal:  Biochemistry       Date:  1971-05-11       Impact factor: 3.162

6.  Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli.

Authors:  H Umezawa; M Okanishi; R Utahara; K Maeda; S Kondo
Journal:  J Antibiot (Tokyo)       Date:  1967-07       Impact factor: 2.649

7.  R factor-mediated aminoglycoside antibiotic resistance in Pseudomonas aeruginosa: a new aminoglycoside 6'-N-acetyltransferase.

Authors:  H Kawabe; S Kondo; H Umezawa; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1975-05       Impact factor: 5.191

8.  Transferrable resistance to tobramycin in Klebsiella pneumoniae and Enterobacter cloacae associated with enzymatic acetylation of tobramycin.

Authors:  B H Minshew; R K Holmes; J P Sanford; C R Baxter
Journal:  Antimicrob Agents Chemother       Date:  1974-10       Impact factor: 5.191
  8 in total
  16 in total

1.  Cloning and sequencing of a gene encoding an aminoglycoside 6'-N-acetyltransferase from an R factor of Citrobacter diversus.

Authors:  F C Tenover; D Filpula; K L Phillips; J J Plorde
Journal:  J Bacteriol       Date:  1988-01       Impact factor: 3.490

Review 2.  Aminoglycoside resistance in Pseudomonas aeruginosa.

Authors:  Keith Poole
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

3.  Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6'-N-acetyltransferase Ib and IIa proteins.

Authors:  P N Rather; H Munayyer; P A Mann; R S Hare; G H Miller; K J Shaw
Journal:  J Bacteriol       Date:  1992-05       Impact factor: 3.490

4.  2"-O-phosphorylation of gentamicin components by a Staphylococcus aureus strain carrying a plasmid.

Authors:  A Martel; N Moreau; M L Capmau; C J Soussy; J Duval
Journal:  Antimicrob Agents Chemother       Date:  1977-07       Impact factor: 5.191

5.  Heterogeneity of 6'-N-acetyltransferases of type 4 conferring resistance to amikacin and related aminoglycosides in members of the family Enterobacteriaceae.

Authors:  G Tran Van Nhieu; E Collatz
Journal:  Antimicrob Agents Chemother       Date:  1988-08       Impact factor: 5.191

6.  Effect of aminoglycoside concentration on reaction rates of aminoglycoside-modifying enzymes.

Authors:  G P Bongaerts; J S Vliegenthart
Journal:  Antimicrob Agents Chemother       Date:  1988-05       Impact factor: 5.191

7.  Enzymatic modification of aminoglycoside antibiotics: 3-N-acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin.

Authors:  J Davies; S O'Connor
Journal:  Antimicrob Agents Chemother       Date:  1978-07       Impact factor: 5.191

8.  Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.

Authors:  S Biddlecome; M Haas; J Davies; G H Miller; D F Rane; P J Daniels
Journal:  Antimicrob Agents Chemother       Date:  1976-06       Impact factor: 5.191

9.  Common plasmid specifying tobramycin resistance found in two enteric bacteria isolated from burn patients.

Authors:  L P Elwell; J M Inamine; B H Minshew
Journal:  Antimicrob Agents Chemother       Date:  1978-02       Impact factor: 5.191

10.  Cross infection in a surgical ward caused by Pseudomonas aeruginosa with transferable resistance to gentamicin and tobramycin.

Authors:  F R Falkiner; C T Keane; M Dalton; M T Clancy; G A Jacoby
Journal:  J Clin Pathol       Date:  1977-08       Impact factor: 3.411
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