Literature DB >> 8768251

Exogenous shikimic acid stimulates rapamycin biosynthesis in Streptomyces hygroscopicus.

A Fang1, A L Demain.   

Abstract

A chemically defined medium was developed which satisfies the nutritional needs of the Streptomyces hygroscopicus strain producing the immunosuppressant rapamycin. More than a doubling of rapamycin biosynthesis was observed on addition of 57 mmol/L of exogenous shikimate. The previously observed inhibition of the synthesis by phenylalanine was not reversed by shikimate.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 8768251     DOI： 10.1007/bf02818516

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  9 in total

1.  Antibiotic biosynthesis.

Authors:  L C Vining
Journal:  Biotechnol Adv       Date:  1985       Impact factor: 14.227

2.  FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

Authors:  T Kino; H Hatanaka; M Hashimoto; M Nishiyama; T Goto; M Okuhara; M Kohsaka; H Aoki; H Imanaka
Journal:  J Antibiot (Tokyo)       Date:  1987-09       Impact factor: 2.649

3.  FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics.

Authors:  H Hatanaka; T Kino; S Miyata; N Inamura; A Kuroda; T Goto; H Tanaka; M Okuhara
Journal:  J Antibiot (Tokyo)       Date:  1988-11       Impact factor: 2.649

4.  Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.

Authors:  C Vézina; A Kudelski; S N Sehgal
Journal:  J Antibiot (Tokyo)       Date:  1975-10       Impact factor: 2.649

5.  Phosphate, ammonium, magnesium and iron nutrition of Streptomyces hygroscopicus with respect to rapamycin biosynthesis.

Authors:  Y R Cheng; L Hauck; A L Demain
Journal:  J Ind Microbiol       Date:  1995-05

6.  Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus.

Authors:  Y R Cheng; A Fang; A L Demain
Journal:  Appl Microbiol Biotechnol       Date:  1995-11       Impact factor: 4.813

Review 7.  Rapamycin: a novel immunosuppressive macrolide.

Authors:  S N Sehgal; K Molnar-Kimber; T D Ocain; B M Weichman
Journal:  Med Res Rev       Date:  1994-01       Impact factor: 12.944

8.  Incorporation of acetate, propionate, and methionine into rapamycin by Streptomyces hygroscopicus.

Authors:  N L Paiva; A L Demain; M F Roberts
Journal:  J Nat Prod       Date:  1991 Jan-Feb       Impact factor: 4.050

9.  Carbon source nutrition of rapamycin biosynthesis in Streptomyces hygroscopicus.

Authors:  I Kojima; Y R Cheng; V Mohan; A L Demain
Journal:  J Ind Microbiol       Date:  1995-06
  9 in total
  8 in total

1.  Comparative metabolic profiling reveals the key role of amino acids metabolism in the rapamycin overproduction by Streptomyces hygroscopicus.

Authors:  Baohua Wang; Jiao Liu; Huanhuan Liu; Di Huang; Jianping Wen
Journal:  J Ind Microbiol Biotechnol       Date:  2015-04-04       Impact factor: 3.346

2.  Enhancement of rapamycin production by metabolic engineering in Streptomyces hygroscopicus based on genome-scale metabolic model.

Authors:  Lanqing Dang; Jiao Liu; Cheng Wang; Huanhuan Liu; Jianping Wen
Journal:  J Ind Microbiol Biotechnol       Date:  2016-12-01       Impact factor: 3.346

3.  Insights into the metabolic mechanism of rapamycin overproduction in the shikimate-resistant Streptomyces hygroscopicus strain UV-II using comparative metabolomics.

Authors:  Huiyan Geng; Huanhuan Liu; Jiao Liu; Cheng Wang; Jianping Wen
Journal:  World J Microbiol Biotechnol       Date:  2017-05-02       Impact factor: 3.312

4.  Origin of the allyl group in FK506 biosynthesis.

Authors:  Dusan Goranovic; Gregor Kosec; Peter Mrak; Stefan Fujs; Jaka Horvat; Enej Kuscer; Gregor Kopitar; Hrvoje Petkovic
Journal:  J Biol Chem       Date:  2010-03-01       Impact factor: 5.157

Review 5.  Rapamycin golden jubilee and still the miraculous drug: a potent immunosuppressant, antitumor, rejuvenative agent, and potential contributor in COVID-19 treatment.

Authors:  Mohamed A Mohamed; Waill A Elkhateeb; Ghoson M Daba
Journal:  Bioresour Bioprocess       Date:  2022-06-13

6.  Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies.

Authors:  Di Huang; Menglei Xia; Shanshan Li; Jianping Wen; Xiaoqiang Jia
Journal:  J Ind Microbiol Biotechnol       Date:  2013-06-19       Impact factor: 3.346

Review 7.  Streptomyces: host for refactoring of diverse bioactive secondary metabolites.

Authors:  Vivek Sharma; Randhir Kaur; Richa Salwan
Journal:  3 Biotech       Date:  2021-06-16       Impact factor: 2.893

8.  Kinetics of rapamycin production by Streptomyces hygroscopicus MTCC 4003.

Authors:  Subhasish Dutta; Bikram Basak; Biswanath Bhunia; Samayita Chakraborty; Apurba Dey
Journal:  3 Biotech       Date:  2013-12-01       Impact factor: 2.406
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.