Literature DB >> 2445721

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

T Kino1, H Hatanaka, M Hashimoto, M Nishiyama, T Goto, M Okuhara, M Kohsaka, H Aoki, H Imanaka.   

Abstract

FK-506, a novel immunosuppressant, has been isolated from the fermentation broth of Streptomyces tsukubaenis No. 9993 as colorless prism and the molecular formula was determined as C44H69NO12.H2O. The compound suppressed immune responses in vitro and in vivo with mice. This immunosuppressive effect was more potent than that of ciclosporin.

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Year:  1987        PMID： 2445721     DOI： 10.7164/antibiotics.40.1249

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  206 in total

Review 1.  Chemical genetics: ligand-based discovery of gene function.

Authors:  B R Stockwell
Journal:  Nat Rev Genet       Date:  2000-11       Impact factor: 53.242

Review 2.  [Practice experience with topical calcineurin inhibitors].

Authors:  J Lübbe
Journal:  Hautarzt       Date:  2003-04-01       Impact factor: 0.751

3.  Combining metabolomics and network analysis to improve tacrolimus production in Streptomyces tsukubaensis using different exogenous feedings.

Authors:  Cheng Wang; Jiao Liu; Huanhuan Liu; Shaoxiong Liang; Jianping Wen
Journal:  J Ind Microbiol Biotechnol       Date:  2017-08-03       Impact factor: 3.346

Review 4.  FK 506 and autoimmune disease: perspective and prospects.

Authors:  A W Thomson; T E Starzl
Journal:  Autoimmunity       Date:  1992       Impact factor: 2.815

5.  Myasthenic crisis after the cessation of FK506 in a patient with myasthenia gravis.

Authors:  Tetsuro Konishi; Mitsuru Sanada; Kazuya Takehana
Journal:  J Neurol       Date:  2004-09       Impact factor: 4.849

6.  Determination of the most influential sources of variability in tacrolimus trough blood concentrations in adult liver transplant recipients: a bottom-up approach.

Authors:  Cécile Gérard; Jeanick Stocco; Anne Hulin; Benoit Blanchet; Céline Verstuyft; François Durand; Filomena Conti; Christophe Duvoux; Michel Tod
Journal:  AAPS J       Date:  2014-02-14       Impact factor: 4.009

7.  Resolution of severe pyoderma gangrenosum in a patient with streaking leukocyte factor disease after treatment with tacrolimus (FK 506).

Authors:  K Abu-Elmagd; D H Van Thiel; B V Jegasothy; J C Jacobs; P Carroll; H Rodriquez-Rilo; C D Ackerman; J J Fung; T E Starzl
Journal:  Ann Intern Med       Date:  1993-10-01       Impact factor: 25.391

8.  Dose study of the immunosuppression of FK 506 in canine lung allo-transplantation.

Authors:  T Fujisawa; Y Saitoh; N Urabe; T Takeda; Y Sekine; M Baba; Y Yamaguchi
Journal:  Surg Today       Date:  1993       Impact factor: 2.549

9.  Genetic relationships among actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and rapamycin.

Authors:  G M Garrity; B K Heimbuch; H Motamedi; A Shafiee
Journal:  J Ind Microbiol       Date:  1993-01

10.  Enhanced liver regeneration in rats treated with 15-deoxyspergualin alone and in combination with FK 506.

Authors:  M Ohtake; N Okamura; T Sakaguchi; T Aono; S Koyama; K Tsukada; K Yoshida; T Muto
Journal:  Gastroenterol Jpn       Date:  1993-04
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