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Literature DB >> 2461926

FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics.

H Hatanaka¹, T Kino, S Miyata, N Inamura, A Kuroda, T Goto, H Tanaka, M Okuhara.

Abstract

FR-900520 and FR-900523, novel neutral macrolide immunosuppressants, were isolated from the cultured broth of Streptomyces hygroscopicus subsp. yakushimaensis No. 7238. Their molecular formulae were determined as C43H69NO12 and C42H67NO12, respectively. The compounds suppressed immune response in vitro. IC50 values of FR-900520 and FR-900523 for mouse mixed lymphocyte reaction were 0.55 nM and 1.6 nM, respectively. FR-900520, the major component, clearly prolonged skin allograft survival in rats.

Entities: Chemical Species

Mesh：

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Year: 1988 PMID： 2461926 DOI： 10.7164/antibiotics.41.1592

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

20 in total

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Journal: J Biomol NMR Date: 1994-05 Impact factor: 2.835

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Authors: R P Meadows; E T Olejniczak; S W Fesik
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5. Calcineurin is required for virulence of Cryptococcus neoformans.

Authors: A Odom; S Muir; E Lim; D L Toffaletti; J Perfect; J Heitman
Journal: EMBO J Date: 1997-05-15 Impact factor: 11.598

Review 6. Microbial peptidyl-prolyl cis/trans isomerases (PPIases): virulence factors and potential alternative drug targets.

Authors: Can M Ünal; Michael Steinert
Journal: Microbiol Mol Biol Rev Date: 2014-09 Impact factor: 11.056

FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics.

1. Identification of solvent-exposed regions of an FK-506 analog, ascomycin, bound to FKBP using a paramagnetic probe.

Review 2. Immunomodulators isolated from microorganisms.

3. Stereospecific assignments of glycine in proteins by stereospecific deuteration and 15N labeling.

4. A computer-based protocol for semiautomated assignments and 3D structure determination of proteins.

5. Calcineurin is required for virulence of Cryptococcus neoformans.

Review 6. Microbial peptidyl-prolyl cis/trans isomerases (PPIases): virulence factors and potential alternative drug targets.

7. Coronafacoyl Phytotoxin Biosynthesis and Evolution in the Common Scab Pathogen Streptomyces scabiei.

Review 8. Functional diversity and pharmacological profiles of the FKBPs and their complexes with small natural ligands.

9. FK-506-binding proteins from streptomycetes producing immunosuppressive macrolactones of the FK-506 type.

10. A 4D HCCH-TOCSY experiment for assigning the side chain 1H and 13C resonances of proteins.