Literature DB >> 7612217

Phosphate, ammonium, magnesium and iron nutrition of Streptomyces hygroscopicus with respect to rapamycin biosynthesis.

Y R Cheng1, L Hauck, A L Demain.   

Abstract

Phosphate, ammonium and magnesium salts interfered with rapamycin production by Streptomyces hygroscopicus at concentrations optimal for growth. These observations point to the existence of phosphorus, magnesium and nitrogen-negative regulation mechanisms for rapamycin biosynthesis. On the other hand, Fe2+ stimulated rapamycin production at concentrations greater than that required for growth.

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Year:  1995        PMID： 7612217     DOI： 10.1007/BF01569962

Source DB:  PubMed          Journal:  J Ind Microbiol        ISSN： 0169-4146


  6 in total

1.  Trace-metal control of specific biosynthetic processes.

Authors:  E D WEINBERG
Journal:  Perspect Biol Med       Date:  1962       Impact factor: 1.416

2.  Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.

Authors:  C Vézina; A Kudelski; S N Sehgal
Journal:  J Antibiot (Tokyo)       Date:  1975-10       Impact factor: 2.649

Review 3.  Rapamycin: a novel immunosuppressive macrolide.

Authors:  S N Sehgal; K Molnar-Kimber; T D Ocain; B M Weichman
Journal:  Med Res Rev       Date:  1994-01       Impact factor: 12.944

4.  Incorporation of acetate, propionate, and methionine into rapamycin by Streptomyces hygroscopicus.

Authors:  N L Paiva; A L Demain; M F Roberts
Journal:  J Nat Prod       Date:  1991 Jan-Feb       Impact factor: 4.050

5.  Improvement in the titer of echinocandin-type antibiotics: a magnesium-limited medium supporting the biphasic production of pneumocandins A0 and B0.

Authors:  J S Tkacz; R A Giacobbe; R L Monaghan
Journal:  J Ind Microbiol       Date:  1993-02

6.  Carbon source nutrition of rapamycin biosynthesis in Streptomyces hygroscopicus.

Authors:  I Kojima; Y R Cheng; V Mohan; A L Demain
Journal:  J Ind Microbiol       Date:  1995-06
  6 in total
  10 in total

1.  Improvement of sordarin production through process optimization: combining traditional approaches with DOE.

Authors:  Thomas P Tully; James S Bergum; Steven R Schwarz; Susan C Durand; Jeffrey M Howell; Ramesh N Patel; Paul M Cino
Journal:  J Ind Microbiol Biotechnol       Date:  2006-11-28       Impact factor: 3.346

2.  Methionine interference in rapamycin production involves repression of demethylrapamycin methyltransferase and S-adenosylmethionine synthetase.

Authors:  W S Kim; Y Wang; A Fang; A L Demain
Journal:  Antimicrob Agents Chemother       Date:  2000-10       Impact factor: 5.191

3.  Comparative metabolic profiling reveals the key role of amino acids metabolism in the rapamycin overproduction by Streptomyces hygroscopicus.

Authors:  Baohua Wang; Jiao Liu; Huanhuan Liu; Di Huang; Jianping Wen
Journal:  J Ind Microbiol Biotechnol       Date:  2015-04-04       Impact factor: 3.346

4.  Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus.

Authors:  Y R Cheng; A Fang; A L Demain
Journal:  Appl Microbiol Biotechnol       Date:  1995-11       Impact factor: 4.813

5.  Exogenous shikimic acid stimulates rapamycin biosynthesis in Streptomyces hygroscopicus.

Authors:  A Fang; A L Demain
Journal:  Folia Microbiol (Praha)       Date:  1995       Impact factor: 2.099

6.  Insights into the metabolic mechanism of rapamycin overproduction in the shikimate-resistant Streptomyces hygroscopicus strain UV-II using comparative metabolomics.

Authors:  Huiyan Geng; Huanhuan Liu; Jiao Liu; Cheng Wang; Jianping Wen
Journal:  World J Microbiol Biotechnol       Date:  2017-05-02       Impact factor: 3.312

Review 7.  An overview of rapamycin: from discovery to future perspectives.

Authors:  Young Ji Yoo; Hanseong Kim; Sung Ryeol Park; Yeo Joon Yoon
Journal:  J Ind Microbiol Biotechnol       Date:  2016-09-09       Impact factor: 3.346

Review 8.  Streptomyces: host for refactoring of diverse bioactive secondary metabolites.

Authors:  Vivek Sharma; Randhir Kaur; Richa Salwan
Journal:  3 Biotech       Date:  2021-06-16       Impact factor: 2.893

Review 9.  The Pho regulon: a huge regulatory network in bacteria.

Authors:  Fernando Santos-Beneit
Journal:  Front Microbiol       Date:  2015-04-30       Impact factor: 5.640

10.  Kinetics of rapamycin production by Streptomyces hygroscopicus MTCC 4003.

Authors:  Subhasish Dutta; Bikram Basak; Biswanath Bhunia; Samayita Chakraborty; Apurba Dey
Journal:  3 Biotech       Date:  2013-12-01       Impact factor: 2.406
  10 in total

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