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Literature DB >> 8590661

Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus.

Abstract

In a chemically defined medium containing aspartate, arginie and histidine to support good growth, addition of L-lysine stimulated rapamycin production by 150%. This was probably due to its conversion to pipecolic acid, a rapamycin precursor. Phenylalanine and methionine interfered in rapamycin production by unknown mechanisms.

Entities: Chemical Species

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Year: 1995 PMID： 8590661 DOI： 10.1007/bf00166931

Source DB: PubMed Journal: Appl Microbiol Biotechnol ISSN： 0175-7598 Impact factor: 4.813

4 in total

1. Effect of cobalt and cyanocobalamin on biosynthesis of A10255, a thiopeptide antibiotic complex.

Authors: M E Favret; L D Boeck
Journal: J Antibiot (Tokyo) Date: 1992-11 Impact factor: 2.649

2. Phosphate, ammonium, magnesium and iron nutrition of Streptomyces hygroscopicus with respect to rapamycin biosynthesis.

Authors: Y R Cheng; L Hauck; A L Demain
Journal: J Ind Microbiol Date: 1995-05

3. Incorporation of acetate, propionate, and methionine into rapamycin by Streptomyces hygroscopicus.

Authors: N L Paiva; A L Demain; M F Roberts
Journal: J Nat Prod Date: 1991 Jan-Feb Impact factor: 4.050

4. Carbon source nutrition of rapamycin biosynthesis in Streptomyces hygroscopicus.

Authors: I Kojima; Y R Cheng; V Mohan; A L Demain
Journal: J Ind Microbiol Date: 1995-06

4 in total

12 in total

1. Methionine interference in rapamycin production involves repression of demethylrapamycin methyltransferase and S-adenosylmethionine synthetase.

Authors: W S Kim; Y Wang; A Fang; A L Demain
Journal: Antimicrob Agents Chemother Date: 2000-10 Impact factor: 5.191

2. Comparative metabolic profiling reveals the key role of amino acids metabolism in the rapamycin overproduction by Streptomyces hygroscopicus.

Authors: Baohua Wang; Jiao Liu; Huanhuan Liu; Di Huang; Jianping Wen
Journal: J Ind Microbiol Biotechnol Date: 2015-04-04 Impact factor: 3.346

3. Exogenous shikimic acid stimulates rapamycin biosynthesis in Streptomyces hygroscopicus.

Authors: A Fang; A L Demain
Journal: Folia Microbiol (Praha) Date: 1995 Impact factor: 2.099

4. Insights into the metabolic mechanism of rapamycin overproduction in the shikimate-resistant Streptomyces hygroscopicus strain UV-II using comparative metabolomics.

Authors: Huiyan Geng; Huanhuan Liu; Jiao Liu; Cheng Wang; Jianping Wen
Journal: World J Microbiol Biotechnol Date: 2017-05-02 Impact factor: 3.312

5. Approaches towards the enhanced production of Rapamycin by Streptomyces hygroscopicus MTCC 4003 through mutagenesis and optimization of process parameters by Taguchi orthogonal array methodology.

Authors: Subhasish Dutta; Bikram Basak; Biswanath Bhunia; Ankan Sinha; Apurba Dey
Journal: World J Microbiol Biotechnol Date: 2017-04-07 Impact factor: 3.312

6. Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies.

Authors: Di Huang; Menglei Xia; Shanshan Li; Jianping Wen; Xiaoqiang Jia
Journal: J Ind Microbiol Biotechnol Date: 2013-06-19 Impact factor: 3.346

Review 7. An overview of rapamycin: from discovery to future perspectives.

Authors: Young Ji Yoo; Hanseong Kim; Sung Ryeol Park; Yeo Joon Yoon
Journal: J Ind Microbiol Biotechnol Date: 2016-09-09 Impact factor: 3.346

8. Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor.

Authors: SangJoon Mo; Yeon-Hee Ban; Je Won Park; Young Ji Yoo; Yeo Joon Yoon
Journal: J Ind Microbiol Biotechnol Date: 2009-09-12 Impact factor: 3.346

9. Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase.

Authors: L E Khaw; G A Böhm; S Metcalfe; J Staunton; P F Leadlay
Journal: J Bacteriol Date: 1998-02 Impact factor: 3.490

Review 10. Streptomyces: host for refactoring of diverse bioactive secondary metabolites.

Authors: Vivek Sharma; Randhir Kaur; Richa Salwan
Journal: 3 Biotech Date: 2021-06-16 Impact factor: 2.893