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Literature DB >> 8657742

Mode of antibacterial action of totarol, a diterpene from Podocarpus nagi.

Abstract

The antimicrobial mechanism of totarol was studied using Pseudomonas aeruginosa IFO 3080. This diterpene inhibited oxygen consumption and respiratory-driven proton translocation in whole cells, and oxidation of NADH in membrane preparation. NADH-cytochrome c reductase was inhibited by totarol while cytochrome c oxidase was not. NADH-DPIP reductase and NADH-CoQ reductase were also inhibited. The site of respiratory inhibition of totarol was thought to be near CoQ in the bacterial electron transport chain.

Entities: Chemical Species

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Year: 1996 PMID： 8657742 DOI： 10.1055/s-2006-957832

Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352

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Cited

17 in total

1. The Synthesis and Antimicrobial Activity of Heterocyclic Derivatives of Totarol.

Authors: Michelle B Kim; Terrence E O'Brien; Jared T Moore; David E Anderson; Marie H Foss; Doug-Las B Weibel; James B Ames; Jared T Shaw
Journal: ACS Med Chem Lett Date: 2012-08-28 Impact factor: 4.345

2. Synthesis of antimicrobial natural products targeting FtsZ: (+)-totarol and related totarane diterpenes.

Authors: Michelle B Kim; Jared T Shaw
Journal: Org Lett Date: 2010-08-06 Impact factor: 6.005

3. Characterization of novel antimicrobial peptoids.

Authors: B Goodson; A Ehrhardt; S Ng; J Nuss; K Johnson; M Giedlin; R Yamamoto; W H Moos; A Krebber; M Ladner; M B Giacona; C Vitt; J Winter
Journal: Antimicrob Agents Chemother Date: 1999-06 Impact factor: 5.191

4. Soil bacteria are differentially affected by the resin of the medicinal plant Pseudognaphalium vira vira and its main component kaurenoic acid.

Authors: F Gil; R De la Iglesia; L Mendoza; B González; M Wilkens
Journal: Microb Ecol Date: 2006-06-10 Impact factor: 4.552

Mode of antibacterial action of totarol, a diterpene from Podocarpus nagi.

1. The Synthesis and Antimicrobial Activity of Heterocyclic Derivatives of Totarol.

2. Synthesis of antimicrobial natural products targeting FtsZ: (+)-totarol and related totarane diterpenes.

3. Characterization of novel antimicrobial peptoids.

4. Soil bacteria are differentially affected by the resin of the medicinal plant Pseudognaphalium vira vira and its main component kaurenoic acid.

5. Inhibitory effect of totarol on exotoxin proteins hemolysin and enterotoxins secreted by Staphylococcus aureus.

6. Inhibitors of bacterial tubulin target bacterial membranes in vivo.

7. The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus.

8. (4bS,8aS)-1-Isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octa-hydro-phenan-thren-2-yl acetate.

9. (+)-Dehydroabietic acid, an abietane-type diterpene, inhibits Staphylococcus aureus biofilms in vitro.

10. (4bS,8aS)-1-Isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octa-hydro-phenan-thren-2-yl benzoate.