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Literature DB >> 20597470

Synthesis of antimicrobial natural products targeting FtsZ: (+)-totarol and related totarane diterpenes.

Abstract

An efficient, convergent synthesis of totarol by a diastereoselective epoxide/alkene/arene bicyclization is described. The reported synthesis enables the preparation of related diterpenes totaradiol and totarolone as well as previously unavailable derivatives that exhibit comparable inhibition of the bacterial cell division protein FtsZ.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2010 PMID： 20597470 PMCID： PMC2927847 DOI： 10.1021/ol100929z

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

33 in total

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5. The synthesis and antibacterial activity of totarol derivatives. Part 1: modifications of ring-C and pro-drugs.

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10. Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus.

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4. The Synthesis and Antimicrobial Activity of Heterocyclic Derivatives of Totarol.

Authors: Michelle B Kim; Terrence E O'Brien; Jared T Moore; David E Anderson; Marie H Foss; Doug-Las B Weibel; James B Ames; Jared T Shaw
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10. A Relay Strategy Actuates Pre-Existing Trisubstituted Olefins in Monoterpenoids for Cross-Metathesis with Trisubstituted Alkenes.

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