Literature DB >> 17664318

The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus.

Eileen C J Smith1, Glenn W Kaatz, Susan M Seo, Neale Wareham, Elizabeth M Williamson, Simon Gibbons.   

Abstract

The phenolic diterpene totarol had good antimicrobial activity against effluxing strains of Staphylococcus aureus. Subinhibitory concentrations reduced the MICs of selected antibiotics, suggesting that it may also be an efflux pump inhibitor (EPI). A totarol-resistant mutant that overexpressed norA was created to separate antimicrobial from efflux inhibitory activity. Totarol reduced ethidium efflux from this strain by 50% at 15 microM (1/4x MIC), and combination studies revealed marked reductions in ethidium MICs. These data suggest that totarol is a NorA EPI as well as an antistaphylococcal antimicrobial agent.

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Year:  2007        PMID： 17664318      PMCID： PMC2168009          DOI： 10.1128/AAC.00216-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

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