Literature DB >> 8385932

On the role of the C-terminus of alpha-calcitonin-gene-related peptide (alpha CGRP). The structure of des-phenylalaninamide37-alpha CGRP and its interaction with the CGRP receptor.

J P O'Connell1, S M Kelly, D P Raleigh, J A Hubbard, N C Price, C M Dobson, B J Smith.   

Abstract

alpha-Calcitonin-gene-related peptide (alpha CGRP) lacking its C-terminal phenylalaninamide residue was found not to bind to its receptor as did full-length (amidated) alpha CGRP. Investigation of the structure of these peptides by c.d. and n.m.r. revealed no significant difference, so it seemed that the effect of deleting the C-terminal phenylalaninamide on the biological activity of alpha CGRP was not by disruption of the peptide's structure. Thus the C-terminal phenylalaninamide is an important factor in this ligand-receptor interaction, and the group itself may interact directly with the receptor.

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Year:  1993        PMID： 8385932      PMCID： PMC1132503          DOI： 10.1042/bj2910205

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  25 in total

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Authors:  S G Amara; J L Arriza; S E Leff; L W Swanson; R M Evans; M G Rosenfeld
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2.  A second human calcitonin/CGRP gene.

Authors:  P H Steenbergh; J W Höppener; J Zandberg; C J Lips; H S Jansz
Journal:  FEBS Lett       Date:  1985-04-22       Impact factor: 4.124

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Authors:  S G Amara; V Jonas; M G Rosenfeld; E S Ong; R M Evans
Journal:  Nature       Date:  1982-07-15       Impact factor: 49.962

4.  Sequence and expression of the chicken calcitonin gene.

Authors:  S Minvielle; M Cressent; M C Delehaye; N Segond; G Milhaud; A Jullienne; M S Moukhtar; F Lasmoles
Journal:  FEBS Lett       Date:  1987-10-19       Impact factor: 4.124

5.  Receptors for calcitonin gene-related peptide on the rat liver plasma membranes.

Authors:  A Yamaguchi; T Chiba; Y Okimura; T Yamatani; T Morishita; A Nakamura; T Inui; T Noda; T Fujita
Journal:  Biochem Biophys Res Commun       Date:  1988-04-15       Impact factor: 3.575

6.  A protein binding assay for adenosine 3':5'-cyclic monophosphate.

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7.  Bradykinin-induced accumulation of [3H]inositol-1-phosphate in human embryonic pituitary tumour cells by activation of a B2-receptor.

Authors:  N A Sharif; J C Hunter; R G Hill; J Hughes
Journal:  Neurosci Lett       Date:  1988-04-12       Impact factor: 3.046

8.  Pharmacological characterization of a receptor for calcitonin gene-related peptide on rat, L6 myocytes.

Authors:  D R Poyner; D P Andrew; D Brown; C Bose; M R Hanley
Journal:  Br J Pharmacol       Date:  1992-02       Impact factor: 8.739

9.  Calcitonin gene-related peptide is a potent vasodilator.

Authors:  S D Brain; T J Williams; J R Tippins; H R Morris; I MacIntyre
Journal:  Nature       Date:  1985 Jan 3-9       Impact factor: 49.962

10.  Receptor coupled events in bradykinin action: rapid production of inositol phosphates and regulation of cytosolic free Ca2+ in a neural cell line.

Authors:  T R Jackson; T J Hallam; C P Downes; M R Hanley
Journal:  EMBO J       Date:  1987-01       Impact factor: 11.598
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  7 in total

1.  Conformational restraints revealing bioactive beta-bend structures for halpha CGRP8-37 at the CGRP2 receptor of the rat prostatic vas deferens.

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Journal:  Br J Pharmacol       Date:  1999-03       Impact factor: 8.739

2.  Bioactive beta-bend structures for the antagonist halpha CGRP(8 - 37) at the CGRP(1) receptor of the rat pulmonary artery.

Authors:  F M Wisskirchen; P M Doyle; S L Gough; C J Harris; I Marshall
Journal:  Br J Pharmacol       Date:  2000-03       Impact factor: 8.739

3.  Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy.

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4.  Slow Internal Dynamics and Charge Expansion in the Disordered Protein CGRP: A Comparison with Amylin.

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Authors:  Y Becker
Journal:  Virus Genes       Date:  1995-01       Impact factor: 2.332

Review 6.  Structure-activity relationships for α-calcitonin gene-related peptide.

Authors:  Harriet A Watkins; Dan L Rathbone; James Barwell; Debbie L Hay; David R Poyner
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

7.  Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding.

Authors:  Sugato Banerjee; Janel Evanson; Erik Harris; Stephen L Lowe; Kathryn A Thomasson; James E Porter
Journal:  BMC Pharmacol       Date:  2006-06-15
  7 in total

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