Literature DB >> 6283379

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products.

S G Amara, V Jonas, M G Rosenfeld, E S Ong, R M Evans.   

Abstract

Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitonin gene-related peptide (CGRP). The calcitonin mRNA predominates in the thyroid while the CGRP-specific mRNA appears to predominate in the hypothalamus. These observations lead us to propose a model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expression.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 6283379     DOI： 10.1038/298240a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  388 in total

1.  The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn).

Authors:  A M Hartmann; O Nayler; F W Schwaiger; A Obermeier; S Stamm
Journal:  Mol Biol Cell       Date:  1999-11       Impact factor: 4.138

Review 2.  Calcitonin and calcitonin receptors: bone and beyond.

Authors:  M Pondel
Journal:  Int J Exp Pathol       Date:  2000-12       Impact factor: 1.925

3.  Mechanism of CGRP-induced relaxation in rat intramural coronary arteries.

Authors:  M Sheykhzade; N C Berg Nyborg
Journal:  Br J Pharmacol       Date:  2001-03       Impact factor: 8.739

4.  CGRP receptors mediating CGRP-, adrenomedullin- and amylin-induced relaxation in porcine coronary arteries. Characterization with 'Compound 1' (WO98/11128), a non-peptide antagonist.

Authors:  P Hasbak; A Sams; S Schifter; J Longmore; L Edvinsson
Journal:  Br J Pharmacol       Date:  2001-08       Impact factor: 8.739

5.  Two distinct forms of the 64,000 Mr protein of the cleavage stimulation factor are expressed in mouse male germ cells.

Authors:  A M Wallace; B Dass; S E Ravnik; V Tonk; N A Jenkins; D J Gilbert; N G Copeland; C C MacDonald
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-08       Impact factor: 11.205

Review 6.  Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis.

Authors:  J Zhao; L Hyman; C Moore
Journal:  Microbiol Mol Biol Rev       Date:  1999-06       Impact factor: 11.056

7.  Short- and long-term influences of calcitonin gene-related peptide on the synthesis of acetylcholinesterase in mammalian myotubes.

Authors:  V L da Costa; A J Lapa; R O Godinho
Journal:  Br J Pharmacol       Date:  2001-05       Impact factor: 8.739

Review 8.  Chemical mediators of migraine: preclinical and clinical observations.

Authors:  Saurabh Gupta; Stephanie J Nahas; B Lee Peterlin
Journal:  Headache       Date:  2011-06       Impact factor: 5.887

9.  Central cardiovascular effects of calcitonin gene-related peptide: interaction with noradrenaline in the nucleus tractus solitarius of rats.

Authors:  M Vallejo; S Lightman; I Marshall
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

10.  Model for tissue specific Calcitonin/CGRP-I RNA processing from in vitro experiments.

Authors:  R A Bovenberg; G J Adema; H S Jansz; P D Baas
Journal:  Nucleic Acids Res       Date:  1988-08-25       Impact factor: 16.971
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.