Literature DB >> 2985435

A second human calcitonin/CGRP gene.

P H Steenbergh, J W Höppener, J Zandberg, C J Lips, H S Jansz.   

Abstract

The calcitonin (CT) gene is alternatively expressed in a tissue-specific fashion producing either the calcium regulatory hormone CT in the thyroid or the neuropeptide calcitonin gene related peptide (CGRP) in the brain. In medullary carcinoma of the thyroid both peptides are produced. We present here evidence for the existence in the human genome of a second CT gene, which is also expressed in human medullary thyroid carcinoma. This gene encodes a second human CGRP, differing from the known human CGRP in 3 of the 37 amino acids.

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Year:  1985        PMID： 2985435     DOI： 10.1016/0014-5793(85)80820-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  51 in total

1.  Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin.

Authors:  J A Hubbard; S R Martin; L C Chaplin; C Bose; S M Kelly; N C Price
Journal:  Biochem J       Date:  1991-05-01       Impact factor: 3.857

2.  Calcitonin gene related peptide.

Authors:  D J O'Halloran; S R Bloom
Journal:  BMJ       Date:  1991-03-30

3.  Identification of a new calcitonin gene in the salmon Oncorhynchus gorbuscha.

Authors:  H Jansz; K Martial; J Zandberg; G Milhaud; A A Benson; A Julienne; M S Moukhtar; M Cressent
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

Review 4.  Inhibition of calcitonin gene-related peptide function: a promising strategy for treating migraine.

Authors:  Paul L Durham
Journal:  Headache       Date:  2008-09       Impact factor: 5.887

5.  Structure and methylation of the human calcitonin/alpha-CGRP gene.

Authors:  P M Broad; A J Symes; R V Thakker; R K Craig
Journal:  Nucleic Acids Res       Date:  1989-09-12       Impact factor: 16.971

6.  The second human calcitonin/CGRP gene is located on chromosome 11.

Authors:  J W Höppener; P H Steenbergh; J Zandberg; A H Geurts van Kessel; S B Baylin; B D Nelkin; H S Jansz; C J Lips
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

Review 7.  Peptides from the calcitonin genes: molecular genetics, structure and function.

Authors:  L H Breimer; I MacIntyre; M Zaidi
Journal:  Biochem J       Date:  1988-10-15       Impact factor: 3.857

Review 8.  Central nervous system binding sites for calcitonin and calcitonin gene-related peptide.

Authors:  P M Sexton
Journal:  Mol Neurobiol       Date:  1991       Impact factor: 5.590

9.  Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine.

Authors:  Paul L Durham; Carrie V Vause
Journal:  CNS Drugs       Date:  2010-07       Impact factor: 5.749

10.  Human alpha-calcitonin gene-related peptide (CGRP) is a potent vasodilator in human mesenteric vasculature.

Authors:  I Marshall; S J Al-Kazwini; J J Holman; R K Craig
Journal:  Br J Clin Pharmacol       Date:  1988-12       Impact factor: 4.335
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