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Literature DB >> 8346237

Integration of gene maps: chromosome 21.

S Lawrence¹, A Collins, B J Keats, M Hulten, N E Morton.

Abstract

Physical, cytogenetic, and genetic data including microsatellite markers and a covering sequence-tagged site (STS) map have been entered into a location database and integrated into a summary map that subsumes a composite physical location, sex-specific genetic locations, cytogenetic and regional assignments, mouse homology, rank, and references. With the omission of 52 loci whose location is known only from cytogenetic assignment to an interval greater than 10 megabases, there are 198 loci in the covering STS map and an additional 145 loci. The physical length is consistent with 11 megabases for 21p and 39 megabases for 21q. With error filtration and allowance for high interference, the genetic length in males corresponds to the chiasma map (54.7 centimorgans), and the genetic length in females is 76.5 centimorgans. The relation between map integration and the STS paradigm is illustrated and discussed.

Entities: Species

Mesh：

Substances：
Genetic Markers

Year: 1993 PMID： 8346237 PMCID： PMC47106 DOI： 10.1073/pnas.90.15.7210

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

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Journal: Ann Hum Genet Date: 1992-07 Impact factor: 1.670

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Journal: Genomics Date: 1990-03 Impact factor: 5.736

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Authors: N E Morton; V Andrews
Journal: Ann Hum Genet Date: 1989-07 Impact factor: 1.670

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Journal: Science Date: 1989-09-29 Impact factor: 47.728

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Authors: T B Shows; P J McAlpine; C Boucheix; F S Collins; P M Conneally; J Frézal; H Gershowitz; P N Goodfellow; J G Hall; P Issitt; C A Jones; B B Knowles; M Lewis; V A McKusick; M Meisler; N E Morton; P Rubenstein; M S Schanfield; R D Schmickel; M H Skolnick; M A Spence; G R Sutherland; M Traver; N Van Cong; H F Willard
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Authors: D A Laurie; M A Hultén
Journal: Ann Hum Genet Date: 1985-07 Impact factor: 1.670

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Journal: Hum Hered Date: 1977 Impact factor: 0.444

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Authors: M A Ferguson-Smith
Journal: FASEB J Date: 1991-01 Impact factor: 5.191

10. Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions.

Authors: K Gardiner; M Horisberger; J Kraus; U Tantravahi; J Korenberg; V Rao; S Reddy; D Patterson
Journal: EMBO J Date: 1990-01 Impact factor: 11.598

10 in total

1. Characterization of human crossover interference.

Authors: K W Broman; J L Weber
Journal: Am J Hum Genet Date: 2000-05-08 Impact factor: 11.025

2. Random-breakage mapping method applied to human DNA sequences.

Authors: M Löbrich; B Rydberg; P K Cooper
Journal: Nucleic Acids Res Date: 1996-05-15 Impact factor: 16.971

3. Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.

Authors: S D Detera-Wadleigh; J A Badner; L R Goldin; W H Berrettini; A R Sanders; D Y Rollins; G Turner; T Moses; H Haerian; D Muniec; J I Nurnberger; E S Gershon
Journal: Am J Hum Genet Date: 1996-06 Impact factor: 11.025

4. A specific superoxide dismutase mutation is on the same genetic background in sporadic and familial cases of amyotrophic lateral sclerosis.

Authors: C Hayward; R J Swingler; S A Simpson; D J Brock
Journal: Am J Hum Genet Date: 1996-11 Impact factor: 11.025

5. Estimating meiotic exchange patterns from recombination data: an application to humans.

Authors: N E Lamb; E Feingold; S L Sherman
Journal: Genetics Date: 1997-07 Impact factor: 4.562

6. Physical structure of human chromosome 21: an analysis of YACs spanning 21q.

Authors: H Ochman; L A Buckholtz
Journal: Mamm Genome Date: 1995-02 Impact factor: 2.957

7. Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends.

Authors: M Löbrich; B Rydberg; P K Cooper
Journal: Proc Natl Acad Sci U S A Date: 1995-12-19 Impact factor: 11.205

8. EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations.

Authors: M Giovannini; J A Biegel; M Serra; J Y Wang; Y H Wei; L Nycum; B S Emanuel; G A Evans
Journal: J Clin Invest Date: 1994-08 Impact factor: 14.808

9. A long-range physical map of human chromosome 21q22.1 band from the YAC continuum.

Authors: T Eki; M Abe; K Furuya; I Ahmad; N Fujishima; H Kishida; A Shiratori; T Onozaki; K Yokoyama; D Le Paslier; D Cohen; F Hanaoka; Y Murakami
Journal: Mamm Genome Date: 1996-04 Impact factor: 2.957

10. Genetic homogeneity of autoimmune polyglandular disease type I.

Authors: P Björses; J Aaltonen; A Vikman; J Perheentupa; G Ben-Zion; G Chiumello; N Dahl; P Heideman; J J Hoorweg-Nijman; L Mathivon; P E Mullis; M Pohl; M Ritzen; G Romeo; M S Shapiro; C S Smith; J Solyom; J Zlotogora; L Peltonen
Journal: Am J Hum Genet Date: 1996-10 Impact factor: 11.025

10 in total