Literature DB >> 8651306

Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.

S D Detera-Wadleigh1, J A Badner, L R Goldin, W H Berrettini, A R Sanders, D Y Rollins, G Turner, T Moses, H Haerian, D Muniec, J I Nurnberger, E S Gershon.   

Abstract

In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008 on nine marker loci. Multilocus ASP analyses revealed locus trios in the distal region between D21S270 and D21S171, with excess allele sharing (nominal P values <.01) under two affection-status models, ASM I (bipolars and schizoaffectives) and ASM II (ASM I plus recurrent unipolars). In addition, under ASM I, the proximal interval spanned by D21S1436 and D21S65 showed locus trios with excess allele sharing (nominal P values of .03-.0003). These findings support prior evidence that a susceptibility locus for bipolar disorder is on 21q.

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Year:  1996        PMID： 8651306      PMCID： PMC1915054     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  30 in total

1.  Continuum of overlapping clones spanning the entire human chromosome 21q.

Authors:  I Chumakov; P Rigault; S Guillou; P Ougen; A Billaut; G Guasconi; P Gervy; I LeGall; P Soularue; L Grinas
Journal:  Nature       Date:  1992-10-01       Impact factor: 49.962

2.  Comparison of a multipoint identity-by-descent method with parametric multipoint linkage analysis for mapping quantitative traits.

Authors:  D E Goldgar; R S Oniki
Journal:  Am J Hum Genet       Date:  1992-03       Impact factor: 11.025

3.  Multipoint analysis of human quantitative genetic variation.

Authors:  D E Goldgar
Journal:  Am J Hum Genet       Date:  1990-12       Impact factor: 11.025

4.  The affected-pedigree-member method of linkage analysis.

Authors:  D E Weeks; K Lange
Journal:  Am J Hum Genet       Date:  1988-02       Impact factor: 11.025

5.  A comparison of sib-pair linkage tests for disease susceptibility loci.

Authors:  W C Blackwelder; R C Elston
Journal:  Genet Epidemiol       Date:  1985       Impact factor: 2.135

6.  A systematic search for a bipolar predisposing locus on chromosome 5.

Authors:  S D Detera-Wadleigh; W H Berrettini; L R Goldin; M Martinez; W T Hsieh; M R Hoehe; I J Encio; D Coffman; D Y Rollins; D Muniec
Journal:  Neuropsychopharmacology       Date:  1992-06       Impact factor: 7.853

7.  Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.

Authors:  P Gregor; R H Reeves; E W Jabs; X Yang; W Dackowski; J M Rochelle; R H Brown; J L Haines; B F O'Hara; G R Uhl
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

8.  Manic depressive illness not linked to factor IX region in an independent series of pedigrees.

Authors:  P V Gejman; S Detera-Wadleigh; M M Martinez; W H Berrettini; L R Goldin; J Gelernter; W T Hsieh; E S Gershon
Journal:  Genomics       Date:  1990-12       Impact factor: 5.736

9.  X-chromosome markers and manic-depressive illness. Rejection of linkage to Xq28 in nine bipolar pedigrees.

Authors:  W H Berrettini; L R Goldin; J Gelernter; P V Gejman; E S Gershon; S Detera-Wadleigh
Journal:  Arch Gen Psychiatry       Date:  1990-04

10.  Genetic linkage between X-chromosome markers and bipolar affective illness.

Authors:  M Baron; N Risch; R Hamburger; B Mandel; S Kushner; M Newman; D Drumer; R H Belmaker
Journal:  Nature       Date:  1987 Mar 19-25       Impact factor: 49.962
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  17 in total

Review 1.  Review of bipolar molecular linkage and association studies.

Authors:  Wade Berrettini
Journal:  Curr Psychiatry Rep       Date:  2002-04       Impact factor: 5.285

2.  Genetics of major mood disorders.

Authors:  Wade Berrettini
Journal:  Psychiatry (Edgmont)       Date:  2004-09

3.  Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype.

Authors:  C Friddle; R Koskela; K Ranade; J Hebert; M Cargill; C D Clark; M McInnis; S Simpson; F McMahon; O C Stine; D Meyers; J Xu; D MacKinnon; T Swift-Scanlan; K Jamison; S Folstein; M Daly; L Kruglyak; T Marr; J R DePaulo; D Botstein
Journal:  Am J Hum Genet       Date:  2000-01       Impact factor: 11.025

4.  Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q.

Authors:  Ping-I Lin; Melvin G McInnis; James B Potash; Virginia L Willour; Dean F Mackinnon; Kuangyi Miao; J Raymond Depaulo; Peter P Zandi
Journal:  Am J Hum Genet       Date:  2005-08-16       Impact factor: 11.025

5.  Two quantitative trait loci for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strains.

Authors:  Tracey L Petryshen; Andrew Kirby; Ronald P Hammer; Shaun Purcell; Sinead B O'Leary; Jonathan B Singer; Annie E Hill; Joseph H Nadeau; Mark J Daly; Pamela Sklar
Journal:  Genetics       Date:  2005-07-05       Impact factor: 4.562

6.  Genetic dissociation of acquisition and memory strength in the heat-box spatial learning paradigm in Drosophila.

Authors:  Soeren Diegelmann; Melissa Zars; Troy Zars
Journal:  Learn Mem       Date:  2006-01-17       Impact factor: 2.460

7.  A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus.

Authors:  V M Aita; J Liu; J A Knowles; J D Terwilliger; R Baltazar; A Grunn; J E Loth; K Kanyas; B Lerer; J Endicott; Z Wang; G Penchaszadeh; T C Gilliam; M Baron
Journal:  Am J Hum Genet       Date:  1999-01       Impact factor: 11.025

8.  Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series.

Authors:  F J McMahon; P J Hopkins; J Xu; M G McInnis; S Shaw; L Cardon; S G Simpson; D F MacKinnon; O C Stine; R Sherrington; D A Meyers; J R DePaulo
Journal:  Am J Hum Genet       Date:  1997-12       Impact factor: 11.025

9.  A follow-up report of a genome search for affective disorder predisposition loci in the Old Order Amish.

Authors:  M C LaBuda; M Maldonado; D Marshall; K Otten; D S Gerhard
Journal:  Am J Hum Genet       Date:  1996-12       Impact factor: 11.025

10.  A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2.

Authors:  S D Detera-Wadleigh; J A Badner; W H Berrettini; T Yoshikawa; L R Goldin; G Turner; D Y Rollins; T Moses; A R Sanders; J D Karkera; L E Esterling; J Zeng; T N Ferraro; J J Guroff; D Kazuba; M E Maxwell; J I Nurnberger; E S Gershon
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205
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