Literature DB >> 3056258

Heterogeneity of 6'-N-acetyltransferases of type 4 conferring resistance to amikacin and related aminoglycosides in members of the family Enterobacteriaceae.

G Tran Van Nhieu1, E Collatz.   

Abstract

DNA-DNA hybridization and immunoblotting were used to assess the relatedness between the 6'-N-acetyltransferases of type 4 encoded by plasmid pAZ007 from a clinical isolate of Serratia marcescens and those encoded by NR79 and R5. The absence of detectable DNA-DNA homology and of immunological cross-reactivity suggests the existence of at least two distinct 6'-N-acetyltransferase type 4 genes that mediate amikacin resistance in gram-negative bacilli.

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Year:  1988        PMID： 3056258      PMCID： PMC172397          DOI： 10.1128/AAC.32.8.1289

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Resistance surveillance programs and the incidence of gram-negative bacillary resistance to amikacin from 1967 to 1985.

Authors:  D N Gerding; T A Larson
Journal:  Am J Med       Date:  1986-06-30       Impact factor: 4.965

2.  Frequency of aminoglycoside 6'-N-acetyltransferase among Serratia species during increased use of amikacin in the hospital.

Authors:  T A Larson; C R Garrett; D N Gerding
Journal:  Antimicrob Agents Chemother       Date:  1986-07       Impact factor: 5.191

3.  Emergence of transferable amikacin resistance in enterobacteria in a Czechoslovakian clinic.

Authors:  V Krcméry; J Havlik
Journal:  J Antimicrob Chemother       Date:  1986-09       Impact factor: 5.790

4.  Characterization of the plasmids comprising the "R factor" R5 and their relationships to other R plasmids.

Authors:  M J Haas; J Davies
Journal:  Plasmid       Date:  1980-05       Impact factor: 3.466

5.  Substrate specificities and structure-activity relationships for acylation of antibiotics catalyzed by kanamycin acetyltransferase.

Authors:  K Radika; D B Northrop
Journal:  Biochemistry       Date:  1984-10-23       Impact factor: 3.162

6.  Characterization of aminoglycoside 6'-N-acetyltransferases [AAC(6')] from gram-negative bacteria and Streptomyces kanamyceticus.

Authors:  J F Meyer; B Wiedemann
Journal:  J Antimicrob Chemother       Date:  1985-03       Impact factor: 5.790

7.  Molecular cloning of amikacin resistance determinants from a Klebsiella pneumoniae plasmid.

Authors:  M E Tolmasky; M Roberts; M Woloj; J H Crosa
Journal:  Antimicrob Agents Chemother       Date:  1986-08       Impact factor: 5.191

8.  Transfer of amikacin resistance by closely related plasmids in members of the family Enterobacteriaceae isolated in Chile.

Authors:  G T Van Nhieu; F W Goldstein; M E Pinto; J F Acar; E Collatz
Journal:  Antimicrob Agents Chemother       Date:  1986-05       Impact factor: 5.191

9.  Purification of two forms of kanamycin acetyltransferase from Escherichia coli.

Authors:  K Radika; D B Northrop
Journal:  Arch Biochem Biophys       Date:  1984-08-15       Impact factor: 4.013

10.  Comparison of aminoglycoside resistance patterns in Japan, Formosa, and Korea, Chile, and the United States.

Authors:  K Shimizu; T Kumada; W C Hsieh; H Y Chung; Y Chong; R S Hare; G H Miller; F J Sabatelli; J Howard
Journal:  Antimicrob Agents Chemother       Date:  1985-08       Impact factor: 5.191
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  1 in total

1.  Appearance of amikacin and tobramycin resistance due to 4'-aminoglycoside nucleotidyltransferase [ANT(4')-II] in gram-negative pathogens.

Authors:  G A Jacoby; M J Blaser; P Santanam; H Hächler; F H Kayser; R S Hare; G H Miller
Journal:  Antimicrob Agents Chemother       Date:  1990-12       Impact factor: 5.191
  1 in total

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