Literature DB >> 8139908

Incorporation of (R)- and (S)-3',4'-seco-thymidine into oligodeoxynucleotides: hybridization properties and enzymatic stability.

P Nielsen1, F Kirpekar, J Wengel.   

Abstract

Novel flexible oligodeoxynucleotide analogues containing (R)- and (S)-3',4'-seco-thymidine were synthesized on an automated DNA-synthesizer using the phosphoramidite approach. Oligodeoxynucleotide analogues (17-mers) having one or three modifications in the middle or one or two modifications in the ends were evaluated with respect to hybridization properties and enzymatic stability. 3'-End-modified oligomers were stable towards 3'-exonuclease degradation and displayed acceptable hybridization properties.

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Year:  1994        PMID： 8139908      PMCID： PMC307872          DOI： 10.1093/nar/22.5.703

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  18 in total

1.  Sugar modified oligonucleotides. I. Carbo-oligodeoxynucleotides as potential antisense agents.

Authors:  M Perbost; M Lucas; C Chavis; A Pompon; H Baumgartner; B Rayner; H Griengl; J L Imbach
Journal:  Biochem Biophys Res Commun       Date:  1989-12-15       Impact factor: 3.575

2.  Incorporation of a complete set of deoxyadenosine and thymidine analogues suitable for the study of protein nucleic acid interactions into oligodeoxynucleotides. Application to the EcoRV restriction endonuclease and modification methylase.

Authors:  P C Newman; V U Nwosu; D M Williams; R Cosstick; F Seela; B A Connolly
Journal:  Biochemistry       Date:  1990-10-23       Impact factor: 3.162

3.  Modified deoxyoligonucleotides stable to exonuclease degradation in serum.

Authors:  J P Shaw; K Kent; J Bird; J Fishback; B Froehler
Journal:  Nucleic Acids Res       Date:  1991-02-25       Impact factor: 16.971

4.  Acyclic analogues of 3'-azido-3'-deoxythymidine as potential antiviral agents. Nucleoside synthesis by Michael addition.

Authors:  P Scheiner; A Geer; A M Bucknor; J L Imbach; R F Schinazi
Journal:  J Med Chem       Date:  1989-01       Impact factor: 7.446

5.  Matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a powerful tool for the mass and sequence analysis of natural and modified oligonucleotides.

Authors:  U Pieles; W Zürcher; M Schär; H E Moser
Journal:  Nucleic Acids Res       Date:  1993-07-11       Impact factor: 16.971

6.  Sugar modified oligonucleotides. III (1). Synthesis, nuclease resistance and base pairing properties of alpha- and beta-L-octathymidylates.

Authors:  F Morvan; C Génu; B Rayner; G Gosselin; J L Imbach
Journal:  Biochem Biophys Res Commun       Date:  1990-10-30       Impact factor: 3.575

7.  Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages.

Authors:  C J Marcus-Sekura; A M Woerner; K Shinozuka; G Zon; G V Quinnan
Journal:  Nucleic Acids Res       Date:  1987-07-24       Impact factor: 16.971

Review 8.  Oligodeoxynucleotides as inhibitors of gene expression: a review.

Authors:  C A Stein; J S Cohen
Journal:  Cancer Res       Date:  1988-05-15       Impact factor: 12.701

9.  New synthetic routes to protected purine 2'-O-methylriboside-3'-O-phosphoramidites using a novel alkylation procedure.

Authors:  B S Sproat; B Beijer; A Iribarren
Journal:  Nucleic Acids Res       Date:  1990-01-11       Impact factor: 16.971

10.  [Synthesis of the anomeres of thymine nucleosides of 2-desoxy-D-ribopyranose].

Authors:  E Wittenburg
Journal:  Chem Ber       Date:  1968
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  4 in total

1.  Oligodeoxynucleoside phosphoramidates (P-NH2): synthesis and thermal stability of duplexes with DNA and RNA targets.

Authors:  S Peyrottes; J J Vasseur; J L Imbach; B Rayner
Journal:  Nucleic Acids Res       Date:  1996-05-15       Impact factor: 16.971

2.  Synthetic incorporation of Nile Blue into DNA using 2'-deoxyriboside substitutes: Representative comparison of (R)- and (S)-aminopropanediol as an acyclic linker.

Authors:  Daniel Lachmann; Sina Berndl; Otto S Wolfbeis; Hans-Achim Wagenknecht
Journal:  Beilstein J Org Chem       Date:  2010-02-09       Impact factor: 2.883

3.  Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template.

Authors:  Ching-Hsuan Tsai; Jingyang Chen; Jack W Szostak
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-04       Impact factor: 11.205

4.  Molecularly resolved, label-free nucleic acid sensing at solid-liquid interface using non-ionic DNA analogues.

Authors:  Tanushree Mana; Jayanta Kundu; Hiya Lahiri; Sudipta Bera; Jayeeta Kolay; Surajit Sinha; Rupa Mukhopadhyay
Journal:  RSC Adv       Date:  2022-03-24       Impact factor: 3.361
  4 in total

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