Literature DB >> 2173569

Sugar modified oligonucleotides. III (1). Synthesis, nuclease resistance and base pairing properties of alpha- and beta-L-octathymidylates.

F Morvan1, C Génu, B Rayner, G Gosselin, J L Imbach.   

Abstract

Two unnatural L-oligodeoxyribonucleotides, namely alpha- and beta-L-dT8pO(CH2)3OH, have been synthesized. These oligomers are resistant towards nuclease degradation. They do not show any UV detectable base pairing with beta-D-dA8 and poly rA.

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Year:  1990        PMID： 2173569     DOI： 10.1016/0006-291x(90)90706-s

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  TAR-RNA binding by HIV-1 Tat protein is selectively inhibited by its L-enantiomer.

Authors:  A Garbesi; F Hamy; M Maffini; G Albrecht; T Klimkait
Journal:  Nucleic Acids Res       Date:  1998-06-15       Impact factor: 16.971

2.  Bioactive and nuclease-resistant L-DNA ligand of vasopressin.

Authors:  K P Williams; X H Liu; T N Schumacher; H Y Lin; D A Ausiello; P S Kim; D P Bartel
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

3.  Synthesis and properties of oligodeoxynucleotides containing the analogue 2'-deoxy-4'-thiothymidine.

Authors:  E L Hancox; B A Connolly; R T Walker
Journal:  Nucleic Acids Res       Date:  1993-07-25       Impact factor: 16.971

4.  Synthesis and properties of mirror-image DNA.

Authors:  H Urata; E Ogura; K Shinohara; Y Ueda; M Akagi
Journal:  Nucleic Acids Res       Date:  1992-07-11       Impact factor: 16.971

5.  4'-Thio-oligo-beta-D-ribonucleotides: synthesis of beta-4'-thio-oligouridylates, nuclease resistance, base pairing properties, and interaction with HIV-1 reverse transcriptase.

Authors:  L Bellon; J L Barascut; G Maury; G Divita; R Goody; J L Imbach
Journal:  Nucleic Acids Res       Date:  1993-04-11       Impact factor: 16.971

6.  Synthesis and physicochemical properties of oligonucleotides built with either alpha-L or beta-L nucleotides units and covalently linked to an acridine derivative.

Authors:  U Asseline; J F Hau; S Czernecki; T Le Diguarher; M C Perlat; J M Valery; N T Thuong
Journal:  Nucleic Acids Res       Date:  1991-08-11       Impact factor: 16.971

7.  An expression based clonality assay at the human androgen receptor locus (HUMARA) on chromosome X.

Authors:  L Busque; J Zhu; D DeHart; B Griffith; C Willman; R Carroll; P M Black; D G Gilliland
Journal:  Nucleic Acids Res       Date:  1994-02-25       Impact factor: 16.971

8.  L-DNAs as potential antimessenger oligonucleotides: a reassessment.

Authors:  A Garbesi; M L Capobianco; F P Colonna; L Tondelli; F Arcamone; G Manzini; C W Hilbers; J M Aelen; M J Blommers
Journal:  Nucleic Acids Res       Date:  1993-09-11       Impact factor: 16.971

9.  Incorporation of (R)- and (S)-3',4'-seco-thymidine into oligodeoxynucleotides: hybridization properties and enzymatic stability.

Authors:  P Nielsen; F Kirpekar; J Wengel
Journal:  Nucleic Acids Res       Date:  1994-03-11       Impact factor: 16.971

Review 10.  The role of the 5' untranslated region of eukaryotic messenger RNAs in translation and its investigation using antisense technologies.

Authors:  K Pantopoulos; H E Johansson; M W Hentze
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1994
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