Literature DB >> 2557019

Sugar modified oligonucleotides. I. Carbo-oligodeoxynucleotides as potential antisense agents.

M Perbost1, M Lucas, C Chavis, A Pompon, H Baumgartner, B Rayner, H Griengl, J L Imbach.   

Abstract

For the first time, carbo-oligodeoxynucleotides, namely c-dT4 and c-dT12, have been synthesized. As compared to the natural oligomers these carbo-oligodeoxynucleotides are at least 5 times more stable toward enzymatic degradation and bind more strongly to complementary DNA. These preliminary data indicate that such oligomers fulfill the requirements to be considered as potential antisense agents.

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Year:  1989        PMID： 2557019     DOI： 10.1016/s0006-291x(89)80029-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

Review 1.  Preclinical and clinical pharmacology of antisense oligonucleotides.

Authors:  E G Marcusson; B R Yacyshyn; W R Shanahan; N M Dean
Journal:  Mol Biotechnol       Date:  1999-08       Impact factor: 2.695

Review 2.  Design and application of antisense oligonucleotides in cell culture, in vivo, and as therapeutic agents.

Authors:  W Brysch; K H Schlingensiepen
Journal:  Cell Mol Neurobiol       Date:  1994-10       Impact factor: 5.046

3.  Synthesis and properties of oligodeoxynucleotides containing the analogue 2'-deoxy-4'-thiothymidine.

Authors:  E L Hancox; B A Connolly; R T Walker
Journal:  Nucleic Acids Res       Date:  1993-07-25       Impact factor: 16.971

4.  Induction of chronic human immunodeficiency virus infection is blocked in vitro by a methylphosphonate oligodeoxynucleoside targeted to a U3 enhancer element.

Authors:  J Laurence; S K Sikder; J Kulkosky; P Miller; P O Ts'o
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103

5.  4'-Thio-oligo-beta-D-ribonucleotides: synthesis of beta-4'-thio-oligouridylates, nuclease resistance, base pairing properties, and interaction with HIV-1 reverse transcriptase.

Authors:  L Bellon; J L Barascut; G Maury; G Divita; R Goody; J L Imbach
Journal:  Nucleic Acids Res       Date:  1993-04-11       Impact factor: 16.971

6.  Investigation of some properties of oligodeoxynucleotides containing 4'-thio-2'-deoxynucleotides: duplex hybridization and nuclease sensitivity.

Authors:  G D Jones; E A Lesnik; S R Owens; L M Risen; R T Walker
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971

7.  Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability.

Authors:  K Augustyns; F Vandendriessche; A Van Aerschot; R Busson; C Urbanke; P Herdewijn
Journal:  Nucleic Acids Res       Date:  1992-09-25       Impact factor: 16.971

8.  An expression based clonality assay at the human androgen receptor locus (HUMARA) on chromosome X.

Authors:  L Busque; J Zhu; D DeHart; B Griffith; C Willman; R Carroll; P M Black; D G Gilliland
Journal:  Nucleic Acids Res       Date:  1994-02-25       Impact factor: 16.971

9.  Incorporation of (R)- and (S)-3',4'-seco-thymidine into oligodeoxynucleotides: hybridization properties and enzymatic stability.

Authors:  P Nielsen; F Kirpekar; J Wengel
Journal:  Nucleic Acids Res       Date:  1994-03-11       Impact factor: 16.971

Review 10.  The role of the 5' untranslated region of eukaryotic messenger RNAs in translation and its investigation using antisense technologies.

Authors:  K Pantopoulos; H E Johansson; M W Hentze
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1994
  10 in total

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