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Literature DB >> 8040284

Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.

Abstract

A genetic map for rat chromosome 2 that includes five candidate genes for blood pressure regulation was constructed in a region containing a quantitative trait locus (QTL) for blood pressure. Two F2 populations of male rats raised on high salt (8% NaCI) diet from weaning were studied: F2(WKY x S), derived from a cross of Dahl salt-sensitive rats (S) and Wistar-Kyoto rats (WKY); and F2(MNS x S), derived from a cross of S rats and Milan normotensive strain (MNS). In both populations a blood pressure QTL was localized between Na+,K(+)-ATPase alpha 1 isoform and calmodulin-dependent protein kinase II-delta loci. The LOD score for existence of this blood pressure QTL based on the combined populations (n = 330) was 5.66 and accounted for 9.2% of the total variance and 26% of the genetic variance.

Entities: Chemical Gene Species

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Substances：

Year: 1994 PMID： 8040284 PMCID： PMC296327 DOI： 10.1172/JCI117341

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

36 in total

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Journal: Nucleic Acids Res Date: 1976-09 Impact factor: 16.971

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Journal: Hypertension Date: 1982 Nov-Dec Impact factor: 10.190

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Authors: J P Rapp; L K Dahl
Journal: Biochemistry Date: 1976-03-23 Impact factor: 3.162

5. A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure.

Authors: J P Rapp; S M Wang; H Dene
Journal: Science Date: 1989-01-27 Impact factor: 47.728

6. Molecular cloning and amino acid sequence of rat enkephalinase.

Authors: B Malfroy; P R Schofield; W J Kuang; P H Seeburg; A J Mason; W J Henzel
Journal: Biochem Biophys Res Commun Date: 1987-04-14 Impact factor: 3.575

7. Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats.

Authors: J P Rapp; H Dene
Journal: Hypertension Date: 1985 May-Jun Impact factor: 10.190

8. Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats.

Authors: C Dubay; M Vincent; N J Samani; P Hilbert; M A Kaiser; J P Beressi; Y Kotelevtsev; J S Beckmann; F Soubrier; J Sassard
Journal: Nat Genet Date: 1993-04 Impact factor: 38.330

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10. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations.

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Journal: Genomics Date: 1987-10 Impact factor: 5.736

14 in total

Review 1. Gene-environment interactions in hypertension.

Authors: Z Pausova; J Tremblay; P Hamet
Journal: Curr Hypertens Rep Date: 1999 Feb-Mar Impact factor: 5.369

2. A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist.

Authors: M Vincent; N J Samani; D Gauguier; J R Thompson; G M Lathrop; J Sassard
Journal: J Clin Invest Date: 1997-10-15 Impact factor: 14.808

10. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat.

Authors: A Y Deng; J P Rapp
Journal: J Clin Invest Date: 1995-05 Impact factor: 14.808

Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.

1. A general method for isolation of high molecular weight DNA from eukaryotes.

2. Mendelian inheritance of 18- and ll beta-steroid hydroxylase activities in the adrenals of rats genetically susceptible or resistant to hypertension.

3. Tail-cuff blood pressure measurement without external preheating in awake rats.

4. Mutant forms of cytochrome P-450 controlling both 18- and 11beta-steroid hydroxylation in the rat.

5. A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure.

6. Molecular cloning and amino acid sequence of rat enkephalinase.

7. Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats.

8. Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats.

9. Plasma mineralocorticoids, plasma renin, and urinary kallikrein in salt-sensitive and salt-resistant rats.

10. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations.

Review 1. Gene-environment interactions in hypertension.

2. A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist.

3. Mapping of rat chromosome 5 markers generated from chromosome-sorted DNA.

4. The alpha1 Na,K-ATPase gene is a susceptibility hypertension gene in the Dahl salt-sensitiveHSD rat.

Review 5. Use of animal models to search for candidate genes associated with essential hypertension.

6. An association between arterial pulse pressure and variation in the fibrillin-1 gene.

7. Chromosomal assignment of 11 loci in the rat by mouse-rat somatic hybrids and linkage.

8. Regulation of blood pressure by the type 1A angiotensin II receptor gene.

9. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1.

10. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat.