Use of animal models to search for candidate genes associated with essential hypertension.

The use of inbred genetically hypertensive animal models enables the dissection of the underlying complex genetic traits into its individual components, and thus the elucidation and characterization of causative genes and gene variants. In addition, genetically hypertensive animal models will also be useful for the investigation of genetic characteristics that influence the effectiveness of antihypertensive therapy with specific pharmacologic agents. This report will discuss three different strategies that have recently been used for the identification of candidate gene loci or candidate genes for hypertension. The possibility to transfer of genetic data derived in animal models to human hypertension will also be considered.