Literature DB >> 710365

Plasma mineralocorticoids, plasma renin, and urinary kallikrein in salt-sensitive and salt-resistant rats.

J P Rapp, S Y Tan, H S Margolius.   

Abstract

Plasma aldosterone, deoxycorticosterone (DOC), 18-hydroxy-deoxycorticosterone (18OH-DOC), and corticosterone were measured in Dahl salt-sensitive (S) and salt-resistant (R) rats. Plasma corticosterone and DOC were not different between strains but plasma aldosterone was decreased and plasma 18OH-DOC increased in S compared to R. Plasma renin activity and urinary kallikrein excretion were both lower in S than R. Urinary kallikrein is known to vary directly with mineralocorticoid activity and 18OH-DOC is a weak mineralocorticoid. The lower urinary kallikrein in the presence of elevated 18OH-DOC could mean that urinary kallikrein differences between S and R are under independent genetic control from 18OH-DOC.

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Year:  1978        PMID： 710365     DOI： 10.3109/07435807809073634

Source DB:  PubMed          Journal:  Endocr Res Commun        ISSN： 0093-6391


  13 in total

1.  A qualitative difference in plasma renin activity in Dahl rats susceptible or resistant to salt-induced hypertension.

Authors:  J P Rapp; R P McPartland; D L Sustarsic
Journal:  Biochem Genet       Date:  1980-12       Impact factor: 1.890

Review 2.  Role of the epithelial sodium channel in salt-sensitive hypertension.

Authors:  Yan Sun; Jia-ning Zhang; Dan Zhao; Qiu-shi Wang; Yu-chun Gu; He-ping Ma; Zhi-ren Zhang
Journal:  Acta Pharmacol Sin       Date:  2011-05-30       Impact factor: 6.150

Review 3.  Role of mineralocorticoid action in the brain in salt-sensitive hypertension.

Authors:  Kenji Oki; Elise P Gomez-Sanchez; Celso E Gomez-Sanchez
Journal:  Clin Exp Pharmacol Physiol       Date:  2012-01       Impact factor: 2.557

Review 4.  The role of transforming growth factor β1 in the regulation of blood pressure.

Authors:  Kota Matsuki; Catherine K Hathaway; Marlon G Lawrence; Oliver Smithies; Masao Kakoki
Journal:  Curr Hypertens Rev       Date:  2014

5.  Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension.

Authors:  Elise P Gomez-Sanchez; Clara M Gomez-Sanchez; Maria Plonczynski; Celso E Gomez-Sanchez
Journal:  Exp Physiol       Date:  2009-10-16       Impact factor: 2.969

6.  Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.

Authors:  A Y Deng; H Dene; J P Rapp
Journal:  J Clin Invest       Date:  1994-07       Impact factor: 14.808

7.  Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats.

Authors:  Licy L Yanes; Julio C Sartori-Valinotti; Radu Iliescu; Damian G Romero; Lorraine C Racusen; Huimin Zhang; Jane F Reckelhoff
Journal:  Am J Physiol Renal Physiol       Date:  2009-02-11

8.  Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats.

Authors:  E M St Lezin; M Pravenec; A L Wong; W Liu; N Wang; S Lu; H J Jacob; R J Roman; D E Stec; J M Wang; I A Reid; T W Kurtz
Journal:  J Clin Invest       Date:  1996-01-15       Impact factor: 14.808

9.  Congenic mapping and sequence analysis of the Renin locus.

Authors:  Michael J Flister; Matthew J Hoffman; Prajwal Reddy; Howard J Jacob; Carol Moreno
Journal:  Hypertension       Date:  2013-03-04       Impact factor: 10.190

Review 10.  Proton channels and renal hypertensive injury: a key piece of the Dahl salt-sensitive rat puzzle?

Authors:  Paul M O'Connor; Avirup Guha; Carly A Stilphen; Jingping Sun; Chunhua Jin
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2016-02-03       Impact factor: 3.619
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