OBJECTIVE: To investigate whether variation in the fibrillin-1 gene was associated with blood pressure in healthy middle aged men, as had been observed in patients with abdominal aortic aneurysm. DESIGN, SETTING, AND PATIENTS: Middle aged men (n = 245), aged 50 to 61 years, were recruited from one of the nine general practices participating in the second Northwick Park heart study. Blood samples were obtained for the preparation of genomic DNA and analysis of plasma variables. MAIN OUTCOME MEASURES: Systolic, diastolic, and pulse pressures; fibrillin-1 genotype characterised with a four allele variable tandem nucleotide repeat polymorphism in intron 28. RESULTS: In healthy middle aged men only three common genotypes were observed: 2-2 (frequency 54.1%), 2-3 (16%) and 2-4 (15%). The mean arterial systolic (and pulse) pressure varied according to fibrillin-1 genotype: 2-4 genotype, 126-3 (47.6) mm Hg; 2-2 genotype, 131.0 (51.3) mm Hg; and 2-3 genotype, 135.5 (54.2) mm Hg. The median pulse pressure was 50 mm Hg. Distribution of men around the median pulse pressure, according to genotype, showed a significant trend for patients of 2-4 genotype to have the lowest pulse pressures, those of 2-2 genotype to have intermediate pressures, and those of 2-3 genotype to have the highest pulse pressures (p = 0.003 for healthy men). CONCLUSIONS: There appears to be a significant association between fibrillin-1 genotype and arterial pulse pressure in men aged 50 to 61 years.
OBJECTIVE: To investigate whether variation in the fibrillin-1 gene was associated with blood pressure in healthy middle aged men, as had been observed in patients with abdominal aortic aneurysm. DESIGN, SETTING, AND PATIENTS: Middle aged men (n = 245), aged 50 to 61 years, were recruited from one of the nine general practices participating in the second Northwick Park heart study. Blood samples were obtained for the preparation of genomic DNA and analysis of plasma variables. MAIN OUTCOME MEASURES: Systolic, diastolic, and pulse pressures; fibrillin-1 genotype characterised with a four allele variable tandem nucleotide repeat polymorphism in intron 28. RESULTS: In healthy middle aged men only three common genotypes were observed: 2-2 (frequency 54.1%), 2-3 (16%) and 2-4 (15%). The mean arterial systolic (and pulse) pressure varied according to fibrillin-1 genotype: 2-4 genotype, 126-3 (47.6) mm Hg; 2-2 genotype, 131.0 (51.3) mm Hg; and 2-3 genotype, 135.5 (54.2) mm Hg. The median pulse pressure was 50 mm Hg. Distribution of men around the median pulse pressure, according to genotype, showed a significant trend for patients of 2-4 genotype to have the lowest pulse pressures, those of 2-2 genotype to have intermediate pressures, and those of 2-3 genotype to have the highest pulse pressures (p = 0.003 for healthy men). CONCLUSIONS: There appears to be a significant association between fibrillin-1 genotype and arterial pulse pressure in men aged 50 to 61 years.
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Authors: Vinicius Tragante; Michael R Barnes; Santhi K Ganesh; Matthew B Lanktree; Wei Guo; Nora Franceschini; Erin N Smith; Toby Johnson; Michael V Holmes; Sandosh Padmanabhan; Konrad J Karczewski; Berta Almoguera; John Barnard; Jens Baumert; Yen-Pei Christy Chang; Clara C Elbers; Martin Farrall; Mary E Fischer; Tom R Gaunt; Johannes M I H Gho; Christian Gieger; Anuj Goel; Yan Gong; Aaron Isaacs; Marcus E Kleber; Irene Mateo Leach; Caitrin W McDonough; Matthijs F L Meijs; Olle Melander; Christopher P Nelson; Ilja M Nolte; Nathan Pankratz; Tom S Price; Jonathan Shaffer; Sonia Shah; Maciej Tomaszewski; Peter J van der Most; Erik P A Van Iperen; Judith M Vonk; Kate Witkowska; Caroline O L Wong; Li Zhang; Amber L Beitelshees; Gerald S Berenson; Deepak L Bhatt; Morris Brown; Amber Burt; Rhonda M Cooper-DeHoff; John M Connell; Karen J Cruickshanks; Sean P Curtis; George Davey-Smith; Christian Delles; Ron T Gansevoort; Xiuqing Guo; Shen Haiqing; Claire E Hastie; Marten H Hofker; G Kees Hovingh; Daniel S Kim; Susan A Kirkland; Barbara E Klein; Ronald Klein; Yun R Li; Steffi Maiwald; Christopher Newton-Cheh; Eoin T O'Brien; N Charlotte Onland-Moret; Walter Palmas; Afshin Parsa; Brenda W Penninx; Mary Pettinger; Ramachandran S Vasan; Jane E Ranchalis; Paul M Ridker; Lynda M Rose; Peter Sever; Daichi Shimbo; Laura Steele; Ronald P Stolk; Barbara Thorand; Mieke D Trip; Cornelia M van Duijn; W Monique Verschuren; Cisca Wijmenga; Sharon Wyatt; J Hunter Young; Aeilko H Zwinderman; Connie R Bezzina; Eric Boerwinkle; Juan P Casas; Mark J Caulfield; Aravinda Chakravarti; Daniel I Chasman; Karina W Davidson; Pieter A Doevendans; Anna F Dominiczak; Garret A FitzGerald; John G Gums; Myriam Fornage; Hakon Hakonarson; Indrani Halder; Hans L Hillege; Thomas Illig; Gail P Jarvik; Julie A Johnson; John J P Kastelein; Wolfgang Koenig; Meena Kumari; Winfried März; Sarah S Murray; Jeffery R O'Connell; Albertine J Oldehinkel; James S Pankow; Daniel J Rader; Susan Redline; Muredach P Reilly; Eric E Schadt; Kandice Kottke-Marchant; Harold Snieder; Michael Snyder; Alice V Stanton; Martin D Tobin; André G Uitterlinden; Pim van der Harst; Yvonne T van der Schouw; Nilesh J Samani; Hugh Watkins; Andrew D Johnson; Alex P Reiner; Xiaofeng Zhu; Paul I W de Bakker; Daniel Levy; Folkert W Asselbergs; Patricia B Munroe; Brendan J Keating Journal: Am J Hum Genet Date: 2014-02-20 Impact factor: 11.025