Literature DB >> 7939663

Quantitative trait locus for reading disability on chromosome 6.

L R Cardon1, S D Smith, D W Fulker, W J Kimberling, B F Pennington, J C DeFries.   

Abstract

Interval mapping of data from two independent samples of sib pairs, at least one member of whom was reading disabled, revealed evidence for a quantitative trait locus (QTL) on chromosome 6. Results obtained from analyses of reading performance from 114 sib pairs genotyped for DNA markers localized the QTL to 6p21.3. Analyses of corresponding data from an independent sample of 50 dizygotic twin pairs provided evidence for linkage to the same region. In combination, the replicate samples yielded a chi 2 value of 16.73 (P = 0.0002). Examination of twin and kindred siblings with more extreme deficits in reading performance yielded even stronger evidence for a QTL (chi 2 = 27.35, P < 0.00001). The position of the QTL was narrowly defined with a 100:1 confidence interval to a 2-centimorgan region within the human leukocyte antigen complex.

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Year:  1994        PMID： 7939663     DOI： 10.1126/science.7939663

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  106 in total

1.  Absence of significant linkage between phonological coding dyslexia and chromosome 6p23-21.3, as determined by use of quantitative-trait methods: confirmation of qualitative analyses.

Authors:  T L Petryshen; B J Kaplan; M F Liu; L L Field
Journal:  Am J Hum Genet       Date:  2000-02       Impact factor: 11.025

2.  Sampling strategies for model free linkage analyses of quantitative traits: implications for sib pair studies of reading and spelling disabilities to minimize the total study cost.

Authors:  A Ziegler
Journal:  Eur Child Adolesc Psychiatry       Date:  1999       Impact factor: 4.785

3.  Reading disability: evidence for a genetic etiology.

Authors:  J Gayán; R K Olson
Journal:  Eur Child Adolesc Psychiatry       Date:  1999       Impact factor: 4.785

4.  Linkage analysis and genetic models in dyslexia--considerations pertaining to discrete trait analysis and quantitative trait analyses.

Authors:  B Müller-Myhsok; T Grimm
Journal:  Eur Child Adolesc Psychiatry       Date:  1999       Impact factor: 4.785

Review 5.  Hyperactivity in children: a focus on genetic research and psychological theories.

Authors:  J Kuntsi; J Stevenson
Journal:  Clin Child Fam Psychol Rev       Date:  2000-03

6.  Relationship inference from trios of individuals, in the presence of typing error.

Authors:  Solveig K Sieberts; Ellen M Wijsman; Elizabeth A Thompson
Journal:  Am J Hum Genet       Date:  2001-11-28       Impact factor: 11.025

7.  Detection and integration of genotyping errors in statistical genetics.

Authors:  Eric Sobel; Jeanette C Papp; Kenneth Lange
Journal:  Am J Hum Genet       Date:  2002-01-08       Impact factor: 11.025

8.  Evidence for linkage and association with reading disability on 6p21.3-22.

Authors:  D E Kaplan; J Gayán; J Ahn; T-W Won; D Pauls; R K Olson; J C DeFries; F Wood; B F Pennington; G P Page; S D Smith; J R Gruen
Journal:  Am J Hum Genet       Date:  2002-04-10       Impact factor: 11.025

9.  The power to detect linkage disequilibrium with quantitative traits in selected samples.

Authors:  G R Abecasis; W O Cookson; L R Cardon
Journal:  Am J Hum Genet       Date:  2001-05-08       Impact factor: 11.025

10.  Use of multivariate linkage analysis for dissection of a complex cognitive trait.

Authors:  Angela J Marlow; Simon E Fisher; Clyde Francks; I Laurence MacPhie; Stacey S Cherny; Alex J Richardson; Joel B Talcott; John F Stein; Anthony P Monaco; Lon R Cardon
Journal:  Am J Hum Genet       Date:  2003-02-13       Impact factor: 11.025
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