Literature DB >> 7566085

A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome.

R R Samaha1, R Green, H F Noller.   

Abstract

Interaction of the conserved CCA terminus of tRNA with rRNA in the peptidyl transferase P site has been studied by in vitro genetics. A watson-Crick G-C pair between G2252 in a conserved hairpin loop of 23S rRNA and C74 at the acceptor end of tRNA is required for proper functional interaction of the CCA end of tRNA with the ribosomal P site. These findings establish a direct role for 23S rRNA in protein synthesis.

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Year:  1995        PMID： 7566085     DOI： 10.1038/377309a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  80 in total

1.  An in vitro evolved precursor tRNA with aminoacylation activity.

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Journal:  EMBO J       Date:  2001-04-02       Impact factor: 11.598

2.  Solution structure of the A loop of 23S ribosomal RNA.

Authors:  S C Blanchard; J D Puglisi
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-20       Impact factor: 11.205

3.  Enhancement of translation by the downstream box does not involve base pairing of mRNA with the penultimate stem sequence of 16S rRNA.

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Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

4.  Interactions between 23S rRNA and tRNA in the ribosomal E site.

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Journal:  RNA       Date:  2001-01       Impact factor: 4.942

5.  Electrostatics of nanosystems: application to microtubules and the ribosome.

Authors:  N A Baker; D Sept; S Joseph; M J Holst; J A McCammon
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-21       Impact factor: 11.205

6.  RNA bound to a solid phase can select an amino acid and facilitate subsequent amide bond formation.

Authors:  A Mellersh; A S Wilkinson
Journal:  Orig Life Evol Biosph       Date:  2000-02       Impact factor: 1.950

7.  The G2447A mutation does not affect ionization of a ribosomal group taking part in peptide bond formation.

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Journal:  RNA       Date:  2003-08       Impact factor: 4.942

8.  The ribosome moves: RNA mechanics and translocation.

Authors:  Harry F Noller; Laura Lancaster; Jie Zhou; Srividya Mohan
Journal:  Nat Struct Mol Biol       Date:  2017-12-07       Impact factor: 15.369

Review 9.  Ribosomal translocation: one step closer to the molecular mechanism.

Authors:  Shinichiro Shoji; Sarah E Walker; Kurt Fredrick
Journal:  ACS Chem Biol       Date:  2009-02-20       Impact factor: 5.100

10.  Puromycin oligonucleotides reveal steric restrictions for ribosome entry and multiple modes of translation inhibition.

Authors:  Shelley R Starck; Richard W Roberts
Journal:  RNA       Date:  2002-07       Impact factor: 4.942
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