Literature DB >> 730179

Deficiency of DNA ligase activity in Fanconi's anemia.

M Hirsch-Kauffmann, M Schweiger, E F Wagner, K Sperling.   

Abstract

A significant decrease in DNA ligase activity was observed in lymphocytes and fibroblasts of a patient with Fanconi's anemia (FA). This decrease is related to the observed DNA repair deficiency indicated by the delayed closing of repair DNA strands following UV irradiation. Other steps of DNA repair were analyzed in the FA fibroblasts, including endonucleolytic incision of DNA, repair DNA synthesis, and exonucleolytic removal of the photoproducts. No differences were found against control cells. The action of DNA ligase is delayed during replication in the FA cells, as seen by an accumulation of replicative intermediates.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 730179     DOI： 10.1007/bf00277570

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  11 in total

Review 1.  Xeroderma pigmentosum: biochemical and genetic characteristics.

Authors:  J E Cleaver; D Bootsma
Journal:  Annu Rev Genet       Date:  1975       Impact factor: 16.830

Review 2.  DNA replication.

Authors:  M L Gefter
Journal:  Annu Rev Biochem       Date:  1975       Impact factor: 23.643

3.  Is Fanconi's anaemia defective in a process essential to the repair of DNA cross links?

Authors:  M S Sasaki
Journal:  Nature       Date:  1975-10-09       Impact factor: 49.962

4.  Fanconi's anemia. I. Case histories, clinical and laboratory findings in six affected siblings.

Authors:  G Prindull; P Stubbe; W Kratzer
Journal:  Z Kinderheilkd       Date:  1975-07-01

5.  Deficiency of gamma-ray excision repair in skin fibroblasts from patients with Fanconi's anemia.

Authors:  J F Remsen; P A Cerutti
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

6.  Formal genetics of Fanconi's anemia.

Authors:  T M Schroeder; D Tilgen; J Krüger; F Vogel
Journal:  Hum Genet       Date:  1976-06-29       Impact factor: 4.132

7.  DNA- and RNA-directed synthesis in vitro of phage enzymes.

Authors:  P Herrlich; M Schweiger
Journal:  Methods Enzymol       Date:  1974       Impact factor: 1.600

8.  A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents.

Authors:  M S Sasaki; A Tonomura
Journal:  Cancer Res       Date:  1973-08       Impact factor: 12.701

9.  Chromosomal peculiarities and "in vitro" examinations in Fanconi's anaemia.

Authors:  D Schuler; A Kiss; F Fábián
Journal:  Humangenetik       Date:  1969

10.  [Spontaneous chromosome aberrations in familial panmyelopathy].

Authors:  T M Schroeder; F Anschütz; A Knopp
Journal:  Humangenetik       Date:  1964
View more
  22 in total

Review 1.  Human DNA repair defects.

Authors:  C F Arlett
Journal:  J Inherit Metab Dis       Date:  1986       Impact factor: 4.982

2.  Fanconi's anaemia: correlation of genetic complementation group with psoralen/UVA response.

Authors:  M Digweed; S Zakrzewski-Lüdcke; K Sperling
Journal:  Hum Genet       Date:  1988-01       Impact factor: 4.132

3.  Fanconi anemia mutation causes cellular susceptibility to ambient oxygen.

Authors:  D Schindler; H Hoehn
Journal:  Am J Hum Genet       Date:  1988-10       Impact factor: 11.025

4.  Antagonistic effect of cocultivation on mitomycin C-induced aberration rate in cells of a patient with Fanconi's anemia and in Chinese hamster ovary cells.

Authors:  S Zakrzewski; K Sperling
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

5.  Complementation studies between Fanconi's anemia cells with different DNA repair characteristics.

Authors:  S Zakrzewski; M Koch; K Sperling
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

6.  Endogenous blockage and delay of the chromosome cycle despite normal recruitment and growth phase explain poor proliferation and frequent edomitosis in Fanconi anemia cells.

Authors:  M Kubbies; D Schindler; H Hoehn; A Schinzel; P S Rabinovitch
Journal:  Am J Hum Genet       Date:  1985-09       Impact factor: 11.025

7.  Chromatid damage after G2 phase x-irradiation of cells from cancer-prone individuals implicates deficiency in DNA repair.

Authors:  R Parshad; K K Sanford; G M Jones
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

8.  Mutagenic effects of isonicotinic acid hydracide in Fanconi's anemia.

Authors:  T M Schroeder; C Stahl-Maugé
Journal:  Hum Genet       Date:  1979       Impact factor: 4.132

9.  The cell cycle of lymphocytes in Fanconi anemia.

Authors:  B Dutrillaux; A Aurias; A M Dutrillaux; D Buriot; M Prieur
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

10.  Transfection of normal human and Chinese hamster DNA corrects diepoxybutane-induced chromosomal hypersensitivity of Fanconi anemia fibroblasts.

Authors:  M Shaham; B Adler; S Ganguly; R S Chaganti
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.