Literature DB >> 535889

Mutagenic effects of isonicotinic acid hydracide in Fanconi's anemia.

T M Schroeder, C Stahl-Maugé.   

Abstract

Isonicotinic acid hydracide (INH) increases substantially the chromosomal instability in Fanconi's anemia (FA) cells. The same concentrations of INH do not significantly break chromosomes in heterozygous or normal cells. INH does not induce alkylation or cross-links in the DNA, like other mutagens known to increase breakage in FA cells. Possible mechanisms of the effect of INH are discussed. One consequence of this experiment is the possibility of an exact and doubtless prenatal diagnosis of a homozygous FA fetus.

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Year:  1979        PMID： 535889     DOI： 10.1007/BF00278680

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  21 in total

1.  Is Fanconi's anaemia defective in a process essential to the repair of DNA cross links?

Authors:  M S Sasaki
Journal:  Nature       Date:  1975-10-09       Impact factor: 49.962

2.  Chromosome preparations of leukocytes cultured from human peripheral blood.

Authors:  P S MOORHEAD; P C NOWELL; W J MELLMAN; D M BATTIPS; D A HUNGERFORD
Journal:  Exp Cell Res       Date:  1960-09       Impact factor: 3.905

3.  Susceptibility of Fanconi's anaemia fibroblasts to chromosome damage by carcinogens.

Authors:  A D Auerbach; S R Wolman
Journal:  Nature       Date:  1976-06-10       Impact factor: 49.962

4.  A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents.

Authors:  M S Sasaki; A Tonomura
Journal:  Cancer Res       Date:  1973-08       Impact factor: 12.701

5.  Microfluorometric detection of deoxyribonucleic acid replication in human metaphase chromosomes.

Authors:  S A Latt
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

6.  Spontaneous chromosomal breakage and high incidence of leukemia in inherited disease.

Authors:  T M Schroeder; R Kurth
Journal:  Blood       Date:  1971-01       Impact factor: 22.113

7.  Carcinogen-induced chromosome breakage in Fanconi's anaemia heterozygous cells.

Authors:  A D Auerbach; S R Wolman
Journal:  Nature       Date:  1978-01-05       Impact factor: 49.962

8.  Deficiency of DNA ligase activity in Fanconi's anemia.

Authors:  M Hirsch-Kauffmann; M Schweiger; E F Wagner; K Sperling
Journal:  Hum Genet       Date:  1978-11-24       Impact factor: 4.132

9.  Inhibition of post-replication repair by isonicotinic acid hydrazide.

Authors:  O L Klamerth
Journal:  Mutat Res       Date:  1978-05       Impact factor: 2.433

10.  Caffeine, caffeine derivatives and chromosomal aberrations. IV. Synergism between Mitomycin C and caffeine in Chinese hamster cells.

Authors:  B Hartley-Asp; B A Kihlman
Journal:  Hereditas       Date:  1971       Impact factor: 3.271
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  8 in total

1.  Antagonistic effect of cocultivation on mitomycin C-induced aberration rate in cells of a patient with Fanconi's anemia and in Chinese hamster ovary cells.

Authors:  S Zakrzewski; K Sperling
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

2.  Cytogenetic studies using various clastogens in two patients with Werner syndrome and control individuals.

Authors:  E Gebhart; M Schinzel; K W Ruprecht
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

3.  Response of lymphocytes from Fanconi's anemia patients and their heterozygous relatives to 8-methoxy-psoralene in a cloning survival test system.

Authors:  E Wunder; B Fleischer-Reischmann
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

4.  Failure of diepoxybutane to enhance sister chromatid exchange levels in Fanconi's anemia patients and heterozygotes.

Authors:  B Porfirio; B Dallapiccola; V Mokini; G Alimena; E Gandini
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

5.  Cytogenetic effects of chemotherapy with three combinations of anti-tubercular drugs involving isoniazid, thiacetazone, para-aminosalicylic acid and streptomycin on human lymphocytes: chromosome aberrations, sister chromatid exchanges and mitotic index.

Authors:  M Jaju; M Jaju; Y R Ahuja
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

6.  The identification of fanconi anemia genotypes by clastogenic stress.

Authors:  M M Cohen; S J Simpson; G R Honig; H S Maurer; J W Nicklas; A O Martin
Journal:  Am J Hum Genet       Date:  1982-09       Impact factor: 11.025

7.  Cytogenetic analyses utilizing various clastogens in two sibs with Fanconi anemia, their relatives, and control individuals.

Authors:  E Gebhart; D Kysela; H Matthee; M Nikol
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

8.  Cytogenetic toxicity of antitumor platinum compounds in Fanconi's anemia.

Authors:  E H Poll; F Arwert; H Joenje; A W Eriksson
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132
  8 in total

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