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Literature DB >> 7193643

Antagonistic effect of cocultivation on mitomycin C-induced aberration rate in cells of a patient with Fanconi's anemia and in Chinese hamster ovary cells.

Abstract

The rate of spontaneous chromosomal aberrations in fibroblasts of a patient with Fanconi's anemia was slightly reduced after cocultivation with Chinese hamster ovary (CHO) cells. However, after mitomycin C treatment, a significant reduction of induced chromosomal damage was found in the FA cells while a significant increase was observed in the CHO cells. This antagonistic effect could be attributed to some diffusible agent(s). The results are discussed with respect to the underlying mechanism of the disease.

Entities: Chemical Disease Species

Mesh：

Substances：
Mitomycins

Year: 1980 PMID： 7193643 DOI： 10.1007/bf00281574

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

18 in total

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Authors: G Prindull; P Stubbe; W Kratzer
Journal: Z Kinderheilkd Date: 1975-07-01

2. Induction by alkylating agents of sister chromatid exchanges and chromatid breaks in Fanconi's anemia.

Authors: S A Latt; G Stetten; L A Juergens; G R Buchanan; P S Gerald
Journal: Proc Natl Acad Sci U S A Date: 1975-10 Impact factor: 11.205

3. Deficiency of gamma-ray excision repair in skin fibroblasts from patients with Fanconi's anemia.

Authors: J F Remsen; P A Cerutti
Journal: Proc Natl Acad Sci U S A Date: 1976-07 Impact factor: 11.205

4. Progeria cells are stimulated to repair DNA by co-cultivation with normal cells.

Authors: W T Brown; J Epstein; J B Little
Journal: Exp Cell Res Date: 1976-02 Impact factor: 3.905

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Authors: M S Sasaki; A Tonomura
Journal: Cancer Res Date: 1973-08 Impact factor: 12.701

6. Frequency of sister chromatid exchanges in Bloom syndrome fibroblasts reduced by cocultivation with normal cells.

Authors: C R Bartram; H W Rüdiger; E Passarge
Journal: Hum Genet Date: 1979-02-15 Impact factor: 4.132

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Authors: D Germain; C Requin
Journal: Nouv Rev Fr Hematol Date: 1970 Jan-Feb

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Authors: D Schuler; A Kiss; F Fábián
Journal: Humangenetik Date: 1969

9. Deficiency of DNA ligase activity in Fanconi's anemia.

Authors: M Hirsch-Kauffmann; M Schweiger; E F Wagner; K Sperling
Journal: Hum Genet Date: 1978-11-24 Impact factor: 4.132

10. Mutagenic effects of isonicotinic acid hydracide in Fanconi's anemia.

Authors: T M Schroeder; C Stahl-Maugé
Journal: Hum Genet Date: 1979 Impact factor: 4.132

6 in total

1. Abnormal response to DNA crosslinking agents of Fanconi anemia fibroblasts can be corrected by transfection with normal human DNA.

Authors: C Diatloff-Zito; D Papadopoulo; D Averbeck; E Moustacchi
Journal: Proc Natl Acad Sci U S A Date: 1986-09 Impact factor: 11.205

2. Abnormal lymphokine production: a novel feature of the genetic disease Fanconi anemia. I. Involvement of interleukin-6.

Authors: F Rosselli; J Sanceau; J Wietzerbin; E Moustacchi
Journal: Hum Genet Date: 1992-04 Impact factor: 4.132

3. Cocultivation of Fanconi anemia cells and of mouse lymphoma mutants leads to interspecies complementation of chromosomal hypersensitivity to DNA cross-linking agents.

Authors: F Rosselli; E Moustacchi
Journal: Hum Genet Date: 1990-05 Impact factor: 4.132