Literature DB >> 7182460

Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtained in vitro as well as on physiological data.

J H Lin, Y Sugiyama, S Awazu, M Hanano.   

Abstract

Ethoxybenzamide (EB) concentrations in plasma and various tissues were simulated using a physiological pharmacokinetic model. The biochemical parameters, such as plasma and tissue binding constants and Michaelis-Menten constants for EB deethylation, which were needed for these simulations, were, however, obtained from in vitro data. The simulations predicted well the observed data in plasma and various tissues of the rat. Furthermore, animal scale-up predicted reasonably well the concentrations of EB in plasma and various tissues of the rabbit from data gathered in rats.

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Year:  1982        PMID： 7182460     DOI： 10.1007/bf01062546

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN： 0090-466X


  18 in total

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Journal:  J Pharmacokinet Biopharm       Date:  1979-04

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Journal:  Biochem Pharmacol       Date:  1972-01       Impact factor: 5.858

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Journal:  J Pharmacokinet Biopharm       Date:  1973-10

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Journal:  J Pharm Sci       Date:  1971-08       Impact factor: 3.534

7.  Lidocaine disposition kinetics in monkey and man. I. Prediction by a perfusion model.

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Journal:  Clin Pharmacol Ther       Date:  1974-07       Impact factor: 6.875

8.  Kinetic studies on the deethylation of ethoxybenzamide. A comparative study with isolated hepatocytes and liver microsomes of rat.

Authors:  J H Lin; Y Sugiyama; S Awazu; M Hanano
Journal:  Biochem Pharmacol       Date:  1980-10-15       Impact factor: 5.858

9.  Species similarities in pharmacokinetics.

Authors:  R L Dedrick; K B Bischoff
Journal:  Fed Proc       Date:  1980-01

10.  Correlation between in vitro and in vivo drug metabolism rate: oxidation of ethoxybenzamide in rat.

Authors:  J H Lin; M Hayashi; S Awazu; M Hanano
Journal:  J Pharmacokinet Biopharm       Date:  1978-08
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  15 in total

1.  A whole-body physiologically based pharmacokinetic model incorporating dispersion concepts: short and long time characteristics.

Authors:  R E Oliver; A F Jones; M Rowland
Journal:  J Pharmacokinet Pharmacodyn       Date:  2001-02       Impact factor: 2.745

2.  Pharmacokinetic and pharmacodynamic evaluation for tissue-selective inhibition of cholesterol synthesis by pravastatin.

Authors:  T Hatanaka; S Honda; S Sasaki; K Katayama; T Koizumi
Journal:  J Pharmacokinet Biopharm       Date:  1998-06

3.  Physicochemical factors associated with binding and retention of compounds in ocular melanin of rats: correlations using data from whole-body autoradiography and molecular modeling for multiple linear regression analyses.

Authors:  P A Zane; S D Brindle; D O Gause; A J O'Buck; P R Raghavan; S L Tripp
Journal:  Pharm Res       Date:  1990-09       Impact factor: 4.200

4.  A novel strategy for physiologically based predictions of human pharmacokinetics.

Authors:  Hannah M Jones; Neil Parrott; Karin Jorga; Thierry Lavé
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447

Review 5.  Pharmacokinetic and pharmacodynamic properties of histamine H2-receptor antagonists. Relationship between intrinsic potency and effective plasma concentrations.

Authors:  J H Lin
Journal:  Clin Pharmacokinet       Date:  1991-03       Impact factor: 6.447

6.  Trapezoidal area method for simulating physiological pharmacokinetics of drugs in animals.

Authors:  X D Liu; J Chen
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1991 Oct-Dec       Impact factor: 2.441

Review 7.  Inhibition and induction of cytochrome P450 and the clinical implications.

Authors:  J H Lin; A Y Lu
Journal:  Clin Pharmacokinet       Date:  1998-11       Impact factor: 6.447

Review 8.  The pharmacokinetic principles behind scaling from preclinical results to phase I protocols.

Authors:  I Mahmood; J D Balian
Journal:  Clin Pharmacokinet       Date:  1999-01       Impact factor: 6.447

9.  Local absorption kinetics of levofloxacin from intestinal tract into portal vein in conscious rat using portal-venous concentration difference.

Authors:  Y Fujieda; K Yamaoka; T Ito; T Nakagawa
Journal:  Pharm Res       Date:  1996-08       Impact factor: 4.200

Review 10.  Receptor-mediated transport of peptide hormones and its importance in the overall hormone disposition in the body.

Authors:  Y Sugiyama; M Hanano
Journal:  Pharm Res       Date:  1989-03       Impact factor: 4.200
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