Literature DB >> 702274

Correlation between in vitro and in vivo drug metabolism rate: oxidation of ethoxybenzamide in rat.

J H Lin, M Hayashi, S Awazu, M Hanano.   

Abstract

In vitro and in vivo correlations of the microsomal oxidation of drugs were examined, using ethoxybenzamide as a model drug. Ethoxybenzamide disappearance time course from rat plasma in vivo was analyzed by a two-compartment model assuming a Michaelis-Menten type elimination process. Ethoxybenazmide oxidation in vitro was measured by the appearance rate of salicylamide in rat liver microsomal suspension. Parameters obtained were Vmax = 3.46 and 3.77 mumoles/min/kg body weight and Km = 0.378 and 0.192 mM, in vitro and in vivo, respectively.

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Year:  1978        PMID： 702274     DOI： 10.1007/bf01060096

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN： 0090-466X


  9 in total

Review 1.  Pharmacokinetics of drug disposition: hemodynamic considerations.

Authors:  G R Wilkinson
Journal:  Annu Rev Pharmacol       Date:  1975       Impact factor: 13.820

2.  Statistical estimations in pharmacokinetics.

Authors:  H G Boxenbaum; S Riegelman; R M Elashoff
Journal:  J Pharmacokinet Biopharm       Date:  1974-04

3.  The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug.

Authors:  R Grundin; P Moldéus; S Orrenius; K O Borg; I Skånberg; C von Bahr
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1974-09

4.  In vitro-in vivo correlation of drug metabolism--deamination of 1- -D-arabinofuranosylcytosine.

Authors:  R L Dedrick; D D Forrester; D H Ho
Journal:  Biochem Pharmacol       Date:  1972-01       Impact factor: 5.858

5.  Blood flow limitations in interpreting Michaelis constants for ethanol oxidation in vivo.

Authors:  R L Dedrick; D D Forrester
Journal:  Biochem Pharmacol       Date:  1973-05-15       Impact factor: 5.858

6.  Animal scale-up.

Authors:  R L Dedrick
Journal:  J Pharmacokinet Biopharm       Date:  1973-10

7.  Pharmacokinetic analysis on the disappearance of ethoxybenzamide from plasma. Statistical treatment of data of two compartmental model by a digital computer.

Authors:  H Nogami; M Hanano; S Awazu; H H Moon
Journal:  Chem Pharm Bull (Tokyo)       Date:  1969-10       Impact factor: 1.645

8.  Kinetics of ethanol metabolism in the intact rat and monkey.

Authors:  A B Makar; G J Mannering
Journal:  Biochem Pharmacol       Date:  1970-06       Impact factor: 5.858

9.  Pharmacokinetics of salicylamide elimination in man.

Authors:  G Levy; T Matsuzawa
Journal:  J Pharmacol Exp Ther       Date:  1967-05       Impact factor: 4.030
  9 in total
  11 in total

1.  Metabolic characterization of a tripeptide human immunodeficiency virus type 1 protease inhibitor, KNI-272, in rat liver microsomes.

Authors:  A Kiriyama; T Nishiura; H Yamaji; K Takada
Journal:  Antimicrob Agents Chemother       Date:  1999-03       Impact factor: 5.191

Review 2.  Pharmacokinetic and pharmacodynamic properties of histamine H2-receptor antagonists. Relationship between intrinsic potency and effective plasma concentrations.

Authors:  J H Lin
Journal:  Clin Pharmacokinet       Date:  1991-03       Impact factor: 6.447

Review 3.  Inhibition and induction of cytochrome P450 and the clinical implications.

Authors:  J H Lin; A Y Lu
Journal:  Clin Pharmacokinet       Date:  1998-11       Impact factor: 6.447

4.  Inhibition of in vitro metabolism of simvastatin by itraconazole in humans and prediction of in vivo drug-drug interactions.

Authors:  M Ishigam; M Uchiyama; T Kondo; H Iwabuchi; S Inoue; W Takasaki; T Ikeda; T Komai; K Ito; Y Sugiyama
Journal:  Pharm Res       Date:  2001-05       Impact factor: 4.200

5.  Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model.

Authors:  Y Igari; Y Sugiyama; Y Sawada; T Iga; M Hanano
Journal:  J Pharmacokinet Biopharm       Date:  1983-12

6.  Comparative physiologically based pharmacokinetics of hexobarbital, phenobarbital and thiopental in the rat.

Authors:  Y Igari; Y Sugiyama; S Awazu; M Hanano
Journal:  J Pharmacokinet Biopharm       Date:  1982-02

7.  Investigations on the in vitro metabolism of five synthetic 19-norprogestins using hepatocyte suspensions isolated from five laboratory animal species.

Authors:  L Qi-Gui; Z Ming-Da; M Hümpel
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1991 Apr-Jun       Impact factor: 2.441

8.  Theoretical consideration of drug distribution kinetics in a noneliminating organ: comparison between a "homogeneous (well-stirred)" model and "nonhomogeneous (tube)" model.

Authors:  T Terasaki; Y Sugiyama; T Iga; Y Sawada; M Hanano
Journal:  J Pharmacokinet Biopharm       Date:  1985-06

9.  Concentration-dependent metabolism of diazepam in mouse liver.

Authors:  M V St-Pierre; K S Pang
Journal:  J Pharmacokinet Biopharm       Date:  1995-06

10.  Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtained in vitro as well as on physiological data.

Authors:  J H Lin; Y Sugiyama; S Awazu; M Hanano
Journal:  J Pharmacokinet Biopharm       Date:  1982-12
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