Literature DB >> 20218010

A review of the applications of physiologically based pharmacokinetic modeling.

K J Himmelstein1, R J Lutz.   

Abstract

The physiological pharmacokinetic approach to the modeling of drug distribution is reviewed. These models allow extrapolation outside the range of data with some confidence if the dominant mechanisms of transport are sufficiently well understood. In addition, it is possible to extrapolate to other species. Compartments correspond to anatomical spaces so that biochemical interactions (including drug effect or pharmacodynamics) can be incorporated in the model. The articles summarized in this review are limited to models dealing with drug application.

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Year:  1979        PMID： 20218010     DOI： 10.1007/bf01059734

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN： 0090-466X


  23 in total

1.  Pharmacokinetic modeling of the dogfish shark (Squalus acanthias): distribution and urinary and biliary excretion of phenol red and its glucuronide.

Authors:  P M Bungay; R L Dedrick; A M Guarino
Journal:  J Pharmacokinet Biopharm       Date:  1976-10

2.  Disposition of cytosine arabinoside (NSC-63878) and its metabolites: a pharmacokinetic simulation.

Authors:  P F Morrison; T L Lincoln; J Aroesty
Journal:  Cancer Chemother Rep       Date:  1975 Jul-Aug

3.  Blood flow limitations in interpreting Michaelis constants for ethanol oxidation in vivo.

Authors:  R L Dedrick; D D Forrester
Journal:  Biochem Pharmacol       Date:  1973-05-15       Impact factor: 5.858

4.  Thiopental pharmacokinetics.

Authors:  K B Bischoff; R L Dedrick
Journal:  J Pharm Sci       Date:  1968-08       Impact factor: 3.534

5.  Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer.

Authors:  R L Dedrick; C E Myers; P M Bungay; V T DeVita
Journal:  Cancer Treat Rep       Date:  1978-01

6.  Preliminary pharmacokinetic model of pilocarpine uptake and distribution in the eye.

Authors:  K J Himmelstein; I Guvenir; T F Patton
Journal:  J Pharm Sci       Date:  1978-05       Impact factor: 3.534

7.  Lidocaine disposition kinetics in monkey and man. I. Prediction by a perfusion model.

Authors:  N Benowitz; F P Forsyth; K L Melmon; M Rowland
Journal:  Clin Pharmacol Ther       Date:  1974-07       Impact factor: 6.875

8.  Pharmacokinetic model for salicyclate in cerebrospinal fluid, blood, organs, and tissues.

Authors:  C N Chen; D L Coleman; J D Andrade; A R Temple
Journal:  J Pharm Sci       Date:  1978-01       Impact factor: 3.534

9.  The kinetics of methotrexate distribution in spontaneous canine lymphosarcoma.

Authors:  R J Lutz; R L Dedrick; J A Straw; M M Hart; P Klubes; D S Zaharko
Journal:  J Pharmacokinet Biopharm       Date:  1975-04

10.  Pharmacokinetics of 1-beta-D-arabinofuranosylcytosine (ARA-C) deamination in several species.

Authors:  R L Dedrick; D D Forrester; J N Cannon; S M el-Dareer; L B Mellett
Journal:  Biochem Pharmacol       Date:  1973-10-01       Impact factor: 5.858
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  31 in total

1.  Significance of binding to Na,K-ATPase in the tissue distribution of ouabain in guinea pigs.

Authors:  H Harashima; M Mamiya; M Yamazaki; Y Sugiyama; Y Sawada; T Iga; M Hanano
Journal:  Pharm Res       Date:  1992-04       Impact factor: 4.200

2.  Kinetic modeling of ouabain tissue distribution based on slow and saturable binding to Na,K-ATPase.

Authors:  H Harashima; M Mamiya; M Yamazaki; Y Sawada; T Iga; M Hanano; Y Sugiyama
Journal:  Pharm Res       Date:  1992-12       Impact factor: 4.200

3.  Physiologically based pharmacokinetic modelling: a sound mechanistic basis is needed.

Authors:  L Aarons
Journal:  Br J Clin Pharmacol       Date:  2005-12       Impact factor: 4.335

4.  Physiological modeling of drug and metabolite: disposition of oxazepam and oxazepam glucuronides in the recirculating perfused mouse liver preparation.

Authors:  M V St-Pierre; D van den Berg; K S Pang
Journal:  J Pharmacokinet Biopharm       Date:  1990-10

Review 5.  The future of open- and closed-loop insulin delivery systems.

Authors:  Terry G Farmer; Thomas F Edgar; Nicholas A Peppas
Journal:  J Pharm Pharmacol       Date:  2008-01       Impact factor: 3.765

Review 6.  Using physiologically-based pharmacokinetic-guided "body-on-a-chip" systems to predict mammalian response to drug and chemical exposure.

Authors:  Jong Hwan Sung; Balaji Srinivasan; Mandy Brigitte Esch; William T McLamb; Catia Bernabini; Michael L Shuler; James J Hickman
Journal:  Exp Biol Med (Maywood)       Date:  2014-06-20

7.  Construction of a whole body blood flow model for use in positron emission tomography imaging with [15O]water.

Authors:  S Narayana; R D Hichwa; L L Ponto; R R Hurtig; G L Watkins
Journal:  J Pharmacokinet Biopharm       Date:  1997-10

Review 8.  Perspectives in pharmacokinetics. Physiologically based pharmacokinetic modeling as a tool for drug development.

Authors:  S B Charnick; R Kawai; J R Nedelman; M Lemaire; W Niederberger; H Sato
Journal:  J Pharmacokinet Biopharm       Date:  1995-04

9.  Revisiting a physiologically based pharmacokinetic model for cocaine with a forensic scope.

Authors:  María Elena Bravo-Gómez; Laura Nayeli Camacho-García; Luz Alejandra Castillo-Alanís; Miguel Ángel Mendoza-Meléndez; Alejandra Quijano-Mateos
Journal:  Toxicol Res (Camb)       Date:  2019-03-13       Impact factor: 3.524

10.  The use of mass balance principles to describe regional drug distribution and elimination.

Authors:  R N Upton; L E Mather; W B Runciman; C Nancarrow; R J Carapetis
Journal:  J Pharmacokinet Biopharm       Date:  1988-02
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