Literature DB >> 1823872

Trapezoidal area method for simulating physiological pharmacokinetics of drugs in animals.

X D Liu1, J Chen.   

Abstract

A trapezoidal area method for simulating physiological pharmacokinetics of drugs in animals is proposed. Concentrations of ethoxybenzamide in rat tissues and diazepam in human plasma were simulated. The results showed that profiles of concentrations vs time in the body with this method were in a good agreement with those obtained with the Rang-Katta method. As compared with the Rang-Katta method, the present method has two special advantages: the time course of drug concentration in tissue can be estimated using simple equations and the speed for simulation is faster.

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Year:  1991        PMID： 1823872     DOI： 10.1007/BF03189973

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  9 in total

1.  [Linear system analysis and physiological model in estimating disposition kinetics of sophocarpine in rats].

Authors:  X D Liu; S K Huang
Journal:  Yao Xue Xue Bao       Date:  1988-07

2.  Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model.

Authors:  Y Igari; Y Sugiyama; Y Sawada; T Iga; M Hanano
Journal:  J Pharmacokinet Biopharm       Date:  1983-12

3.  Comparative physiologically based pharmacokinetics of hexobarbital, phenobarbital and thiopental in the rat.

Authors:  Y Igari; Y Sugiyama; S Awazu; M Hanano
Journal:  J Pharmacokinet Biopharm       Date:  1982-02

4.  Lidocaine disposition kinetics in monkey and man. I. Prediction by a perfusion model.

Authors:  N Benowitz; F P Forsyth; K L Melmon; M Rowland
Journal:  Clin Pharmacol Ther       Date:  1974-07       Impact factor: 6.875

5.  The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

Authors:  U Klotz; G R Avant; A Hoyumpa; S Schenker; G R Wilkinson
Journal:  J Clin Invest       Date:  1975-02       Impact factor: 14.808

6.  Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat.

Authors:  U Klotz; K H Antonin; P R Bieck
Journal:  J Pharmacol Exp Ther       Date:  1976-10       Impact factor: 4.030

7.  Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtained in vitro as well as on physiological data.

Authors:  J H Lin; Y Sugiyama; S Awazu; M Hanano
Journal:  J Pharmacokinet Biopharm       Date:  1982-12

8.  A physiologically based pharmacokinetic model for theophylline disposition in the pregnant and nonpregnant rat.

Authors:  J L Gabrielsson; L K Paalzow; L Nordström
Journal:  J Pharmacokinet Biopharm       Date:  1984-04

9.  A model for the kinetics of distribution of actinomycin-D in the beagle dog.

Authors:  R J Lutz; W M Galbraith; R L Dedrick; R Shrager; L B Mellett
Journal:  J Pharmacol Exp Ther       Date:  1977-03       Impact factor: 4.030
  9 in total

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