Literature DB >> 70989

The effect of beta-adrenergic blocking drugs and inhibitors of phosphodiestease on histamine release from isolated mast cells.

R Nosál, Z Menyhardtová.   

Abstract

Differences in the histamine liberation from isolated rat mast cells after beta-adrenergic blocking drugs were demonstrated. In equimolar concentrations histamine release was induced by Kö 1124, Kö 1500, Kö 1560, Kö 1561 and propranolol. Alprenolol, oxprenolol, propranolol, and trimepranol significantly decreased thehistamine release induced by compound 48-80. The release of granules from cells was inhibited quantitatively more than the release of histamine. This enabled us to surmise the selective effect of beta-adrenergic blocking drugs on cell membranes of mast cells. The possible mechanisms of release reaction are discussed.

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Year:  1977        PMID： 70989     DOI： 10.1007/BF01969978

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  25 in total

1.  Proteolytic enzymes of mast cells.

Authors:  D LAGUNOFF; E P BENDITT
Journal:  Ann N Y Acad Sci       Date:  1963-02-26       Impact factor: 5.691

2.  A study on morphological changes and histamine release induced by compound 48/80 in rat peritoneal mast cells.

Authors:  G D Bloom; O Haegermark
Journal:  Exp Cell Res       Date:  1965-12       Impact factor: 3.905

3.  General concepts in the use of beta-blockers: the relative roles of specific and unspecific effects.

Authors:  H Brunner; P R Hedwall; M Meier
Journal:  Naunyn Schmiedebergs Arch Pharmakol       Date:  1971

4.  Protection against histamine shock by catecholamines in Bordetella pertussis-treated, adrenalectomized, or adrenergic blocked mice.

Authors:  R K Bergman; J Munoz
Journal:  Proc Soc Exp Biol Med       Date:  1966-06

5.  Histamine release from rat mast cells by dextran: effects of adrenergic agents, theophylline and other drugs.

Authors:  J H Baxter
Journal:  Proc Soc Exp Biol Med       Date:  1972-11

Review 6.  Current concepts on the secretory function of mast cells.

Authors:  A Goth; A R Johnson
Journal:  Life Sci       Date:  1975-04-15       Impact factor: 5.037

7.  Quantitative correlation between degranulation and histamine release following exposure of rat mast cells to compound 48-80 in vitro.

Authors:  R Nósal; S A Slorach; B Uvnäs
Journal:  Acta Physiol Scand       Date:  1970-10

Review 8.  The molecular basis for the storage and release of histamine in rat mast cell granules.

Authors:  B Uvnäs
Journal:  Life Sci       Date:  1974-06-16       Impact factor: 5.037

9.  Measurement of hydrophobicity, surface activity, local anaesthesia, and myocardial conduction velocity as quantitative parameters of the non-specific membrane affinity of nine -adrenergic blocking agents.

Authors:  D Hellenbrecht; B Lemmer; G Wiethold; H Grobecker
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

10.  Membrane effects of beta-adrenergic blocking agents: investigations with the fluorescence probe 1-anilino-8-naphthalene sulfonate (ANS) and antihemolytic activities.

Authors:  G Wiethold; D Hellenbrecht; B Lemmer; D Palm
Journal:  Biochem Pharmacol       Date:  1973-06-15       Impact factor: 5.858
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  9 in total

1.  Atenolol, exaprolol and mast cell membranes.

Authors:  J Pecivová; K Drábiková; V Jancinová; M Petríková; R Nosál
Journal:  Agents Actions       Date:  1991-05

2.  Beta-adrenoceptor blocking drugs and calcium transport in isolated rat mast cells.

Authors:  K Drábiková; J Pecivová; R Nosál
Journal:  Agents Actions       Date:  1989-04

3.  The effect of beta-adrenoceptor blocking drugs on histamine liberation, prostaglandin synthesis and phospholipid turnover in isolated mast cells stimulated with concanavalin A.

Authors:  K Drábiková; J Pecivová; M Petríková; V Jancinová; R Nosál
Journal:  Agents Actions       Date:  1990-04

4.  Quantitative correlation between histamine and 35S release from isolated rat mast cells due to the beta-adrenergic blocking drug Kö 1124.

Authors:  R Nosál; J Pecivová; K Drábiková
Journal:  Agents Actions       Date:  1981-07

5.  What - if any - is the role of adrenergic mechanisms in histamine release from mast cells?

Authors:  P E Alm; G D Bloom
Journal:  Agents Actions       Date:  1981-04

6.  On the interaction of beta-adrenoceptor-blocking drugs with isolated mast cells.

Authors:  R Nosál; J Pecivová; K Drábiková
Journal:  Agents Actions       Date:  1985-09

7.  Presence of functionally active beta-adrenoceptors in rat mast cells. Correlation between (--)[3H]-dihydroalprenolol binding and inhibition of histamine release.

Authors:  E Masini; R Fantozzi; P Blandina; A Galli; T Bani-Sacchi; A Giotti; L Zilletti; P F Mannaioni
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-12       Impact factor: 3.000

8.  Evidence for intracellular histamine liberation in isolated rat mast cells.

Authors:  R Nosál; J Pecivova; K Drábiková
Journal:  Agents Actions       Date:  1982-12

9.  Histamine liberation and membrane fluidisation of mast cells exposed to the beta-adrenoceptor blocking drug propranolol.

Authors:  R Nosál; K Ondrias; J Pecivová; K Drábiková
Journal:  Agents Actions       Date:  1988-04
  9 in total

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