Literature DB >> 2455973

Histamine liberation and membrane fluidisation of mast cells exposed to the beta-adrenoceptor blocking drug propranolol.

R Nosál1, K Ondrias, J Pecivová, K Drábiková.   

Abstract

Propranolol liberates histamine from isolated mast cells and decreases the uptake of extracellular histamine in a dose-dependent way. Histamine liberation due to propranolol is accompanied by calcium displacement from intracellular storage sites. The significant increase in membrane fluidity due to propranolol is temperature dependent. The perturbation of membranes is most probably the explanation of propranolol's interaction with isolated rat mast cells which results in altered histamine transportation.

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Year:  1988        PMID： 2455973     DOI： 10.1007/bf02142523

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  9 in total

1.  On the relationship between incorporation of 32P into phospholipids and binding of beta-adrenoceptor blocking drugs to isolated mast cells.

Authors:  J Pecivová; K Drábiková; V Jancinová; R Nosál
Journal:  Agents Actions       Date:  1988-04

2.  Propranolol-induced bronchoconstriction: a non-specific side-effect of beta-adrenergic blocking therapy.

Authors:  G K Terpstra; J A Raaijmakers; G A Wassink
Journal:  Eur J Pharmacol       Date:  1981-07-17       Impact factor: 4.432

3.  The effect of beta-adrenergic blocking drugs and inhibitors of phosphodiestease on histamine release from isolated mast cells.

Authors:  R Nosál; Z Menyhardtová
Journal:  Agents Actions       Date:  1977-07

4.  Effect of propranolol on ventilatory function.

Authors:  R S McNeill; C G Ingram
Journal:  Am J Cardiol       Date:  1966-09       Impact factor: 2.778

5.  The interaction of beta-adrenoceptor blocking drugs with platelet aggregation, calcium displacement and fluidization of the membrane.

Authors:  R Nosál; V Jancinová; K Ondrias; J Jakubovský; P Balgavý
Journal:  Biochim Biophys Acta       Date:  1985-12-05

6.  On the interaction of beta-adrenoceptor-blocking drugs with isolated mast cells.

Authors:  R Nosál; J Pecivová; K Drábiková
Journal:  Agents Actions       Date:  1985-09

7.  Comparisons of the interaction of propranolol and timolol with model and biological membrane systems.

Authors:  L Herbette; A M Katz; J M Sturtevant
Journal:  Mol Pharmacol       Date:  1983-09       Impact factor: 4.436

8.  Evidence for intracellular histamine liberation in isolated rat mast cells.

Authors:  R Nosál; J Pecivova; K Drábiková
Journal:  Agents Actions       Date:  1982-12

9.  Amine transport in isolated rat mast cells treated with betaadrenoceptor blocking drugs.

Authors:  R Nosál; J Pecivová; K Drábiková
Journal:  Agents Actions       Date:  1986-04
  9 in total
  5 in total

1.  Membrane perturbing activity of beta-adrenoceptor blocking drugs in isolated rat mast cells.

Authors:  R Nosál; K Drábiková; J Pecivová; K Ondrias
Journal:  Agents Actions       Date:  1989-04

2.  Histamine liberation as a result of nonreceptor interaction.

Authors:  R Nosál; K Drábiková; J Pecivová; J Jakubovský
Journal:  Agents Actions       Date:  1990-04

3.  Iron uptake and release by macrophages is sensitive to propranolol.

Authors:  Andrei M Komarov; Jonathon M Hall; Joanna J Chmielinska; William B Weglicki
Journal:  Mol Cell Biochem       Date:  2006-05-23       Impact factor: 3.396

4.  Topical ophthalmic beta blockers may cause release of histamine through cytotoxic effects on inflammatory cells.

Authors:  L M van Beek; M Mulder; N J van Haeringen; A Kijlstra
Journal:  Br J Ophthalmol       Date:  2000-09       Impact factor: 4.638

5.  Effect of beta-adrenoceptor blocking drugs on 32P incorporation into and arachidonic acid liberation from phospholipids in stimulated rat mast cells.

Authors:  J Pecivová; K Drábiková; R Nosál
Journal:  Agents Actions       Date:  1989-04
  5 in total

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