Literature DB >> 1680276

Atenolol, exaprolol and mast cell membranes.

J Pecivová1, K Drábiková, V Jancinová, M Petríková, R Nosál.   

Abstract

Lipophilic exaprolol and hydrophilic atenolol differ in their interaction with mast cell membranes. Exaprolol, as compared with atenolol, significantly decreased 32P incorporation into, but increased arachidonic acid liberation from, membrane phospholipids. Moreover, exaprolol significantly decreased phosphate incorporation in compound 48/80 and ConA-PS treated cells and decreased thromboxane formation in stimulated cells. On the other hand, atenolol decreased significantly only arachidonate liberation from stimulated mast cells. These results corroborate to some extent the effect of exaprolol and atenolol on histamine liberation which correlates with their membrane perturbing properties.

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Year:  1991        PMID： 1680276     DOI： 10.1007/bf01993122

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  10 in total

1.  Membrane perturbing activity of beta-adrenoceptor blocking drugs in isolated rat mast cells.

Authors:  R Nosál; K Drábiková; J Pecivová; K Ondrias
Journal:  Agents Actions       Date:  1989-04

2.  Selectivity of beta-adrenoceptor agonists and antagonists in asthmatics.

Authors:  C G Löfdahl
Journal:  Eur J Respir Dis Suppl       Date:  1982

3.  Propranolol, chlorpromazine and platelet membrane: a fluorescence study of the drug-membrane interaction.

Authors:  J Dachary-Prigent; J Dufourcq; C Lussan; M Boisseau
Journal:  Thromb Res       Date:  1979-01       Impact factor: 3.944

4.  On the relationship between incorporation of 32P into phospholipids and binding of beta-adrenoceptor blocking drugs to isolated mast cells.

Authors:  J Pecivová; K Drábiková; V Jancinová; R Nosál
Journal:  Agents Actions       Date:  1988-04

5.  Classification of beta-blocking agents by their inhibitory effects on phospholipase activity.

Authors:  S Nagai; S Sugiyama; T Ozawa
Journal:  Jpn Circ J       Date:  1986-03

6.  The effect of beta-adrenergic blocking drugs and inhibitors of phosphodiestease on histamine release from isolated mast cells.

Authors:  R Nosál; Z Menyhardtová
Journal:  Agents Actions       Date:  1977-07

7.  The effect of beta-adrenoceptor blocking drugs on histamine liberation, prostaglandin synthesis and phospholipid turnover in isolated mast cells stimulated with concanavalin A.

Authors:  K Drábiková; J Pecivová; M Petríková; V Jancinová; R Nosál
Journal:  Agents Actions       Date:  1990-04

8.  Comparisons of the interaction of propranolol and timolol with model and biological membrane systems.

Authors:  L Herbette; A M Katz; J M Sturtevant
Journal:  Mol Pharmacol       Date:  1983-09       Impact factor: 4.436

9.  Suppression by phospholipase A2 inhibitors of secretion of catecholamines from isolated adrenal medullary cells by suppression of cellular calcium uptake.

Authors:  A Wada; S Sakurai; H Kobayashi; N Yanagihara; F Izumi
Journal:  Biochem Pharmacol       Date:  1983-04-01       Impact factor: 5.858

10.  Diacylglycerol lipase activity in human platelet intracellular and surface membranes. Some kinetic properties and fatty acid specificity.

Authors:  K S Authi; M Lagarde; N Crawford
Journal:  FEBS Lett       Date:  1985-01-21       Impact factor: 4.124
  10 in total

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