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Literature DB >> 2473626

Beta-adrenoceptor blocking drugs and calcium transport in isolated rat mast cells.

Abstract

The beta-adrenoceptor blocking (BAB) drugs exaprolol (EXA), metipranolol (MET) and propranolol (PRO) inhibited histamine liberation and degranulation from isolated rat mast cells stimulated with the calcium ionophore A23187. MET was the most and EXA the least active. Atenolol (ATE) had no effect. Inhibition by BAB drugs of secretion induced with A23187 was not accompanied by any change in 45Ca uptake. On the other hand, EXA, MET and PRO significantly decreased 45Ca uptake by mast cells stimulated with 48/80. The effect of BAB drugs on inhibition of A23187-induced secretion from isolated mast cells was dependent on the lipid solubility of the studied drugs.

Entities: Chemical Species

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Year: 1989 PMID： 2473626 DOI： 10.1007/bf02222190

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

7 in total

1. Uptake of anticoagulants by isolated rat hepatocytes.

Authors: W D Wosilait; M P Ryan; K H Byington
Journal: Drug Metab Dispos Date: 1981 Mar-Apr Impact factor: 3.922

2. Role of intra- and extracellular calcium in histamine release from rat peritoneal mast cells.

Authors: F L Pearce; M Ennis; A Truneh; J R White
Journal: Agents Actions Date: 1981-04

3. The effect of beta-adrenergic blocking drugs and inhibitors of phosphodiestease on histamine release from isolated mast cells.

Authors: R Nosál; Z Menyhardtová
Journal: Agents Actions Date: 1977-07

2 in total

1. The effect of beta-adrenoceptor blocking drugs on histamine liberation, prostaglandin synthesis and phospholipid turnover in isolated mast cells stimulated with concanavalin A.

Authors: K Drábiková; J Pecivová; M Petríková; V Jancinová; R Nosál
Journal: Agents Actions Date: 1990-04

2. Effect of beta-adrenoceptor blocking drugs on 32P incorporation into and arachidonic acid liberation from phospholipids in stimulated rat mast cells.

Authors: J Pecivová; K Drábiková; R Nosál
Journal: Agents Actions Date: 1989-04

2 in total

Beta-adrenoceptor blocking drugs and calcium transport in isolated rat mast cells.

1. Uptake of anticoagulants by isolated rat hepatocytes.

2. Role of intra- and extracellular calcium in histamine release from rat peritoneal mast cells.

3. The effect of beta-adrenergic blocking drugs and inhibitors of phosphodiestease on histamine release from isolated mast cells.

4. The effect of Trimepranol on thrombocyte function and histamin release in the rat.

5. On the interaction of beta-adrenoceptor-blocking drugs with isolated mast cells.

6. Evidence for intracellular histamine liberation in isolated rat mast cells.

7. The relationship between histamine secretion and 45calcium uptake by mast cells.

1. The effect of beta-adrenoceptor blocking drugs on histamine liberation, prostaglandin synthesis and phospholipid turnover in isolated mast cells stimulated with concanavalin A.

2. Effect of beta-adrenoceptor blocking drugs on 32P incorporation into and arachidonic acid liberation from phospholipids in stimulated rat mast cells.