Literature DB >> 7095101

The effect of activated dimethicone, other antacid constituents, and kaolin on the absorption of propranolol.

J C McElnay, P F D'Arcy, J K Leonard.   

Abstract

A study was made of the effect of 6 commonly used gastrointestinal preparations on the absorption of propranolol using an in vitro experimental model. The constituents examined were activated dimethicone, aluminium hydroxide gel, bismuth carbonate, kaolin, magnesium carbonate, and magnesium trisilicate. A slight decreased propranolol absorption was given by kaolin (-13.0%), the other components showed smaller effects ranging from -6.8% to +6.6%. None of the results were statistically significantly different from control absorption values.

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Year:  1982        PMID： 7095101     DOI： 10.1007/BF02327075

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  9 in total

1.  An in vitro model of drug-metal ion interactions in the gut [proceedings].

Authors:  P F D'Arcy; H A Muhyiddin; J McElnay
Journal:  J Pharm Pharmacol       Date:  1976-12       Impact factor: 3.765

2.  Decreased bioavailability of digoxin due to antacids and kaolin-pectin.

Authors:  D D Brown; R P Juhl
Journal:  N Engl J Med       Date:  1976-11-04       Impact factor: 91.245

3.  Everted rat intestinal sacs as an in vitro model for assessing absorptivity of new drugs.

Authors:  Z T Chowhan; A A Amaro
Journal:  J Pharm Sci       Date:  1977-09       Impact factor: 3.534

4.  Interference of iron with the absorption of tetracyclines in man.

Authors:  P J Neuvonen; G Gothoni; R Hackman; K Björksten
Journal:  Br Med J       Date:  1970-11-28

5.  Effects of antacids on gastrointestinal absorption of drugs.

Authors:  J A Romankiewicz
Journal:  Prim Care       Date:  1976-09       Impact factor: 2.907

6.  Interaction between phenytoin and antacids.

Authors:  V K Kulshrestha; M Thomas; J Wadsworth; A Richens
Journal:  Br J Clin Pharmacol       Date:  1978-08       Impact factor: 4.335

7.  The uptake of digoxin and digitoxin by some antacids.

Authors:  S A Khalil
Journal:  J Pharm Pharmacol       Date:  1974-12       Impact factor: 3.765

8.  The interaction of warfarin with antacid constituents in the gut.

Authors:  J C McElnay; D W Harron; P F D'Arcy; P S Collier
Journal:  Experientia       Date:  1979-10-15

9.  Interaction of digoxin with activated dimethicone and other antacid constituents.

Authors:  J C McElnay; D W Harron; P F D'Arcy; M R Eagle
Journal:  Experientia       Date:  1979-01-15
  9 in total
  2 in total

1.  Repetitive Position Change Improves Gastric Cleanliness for Magnetically Controlled Capsule Gastroscopy.

Authors:  Yuan-Chen Wang; Jun Pan; Xi Jiang; Xiao-Ju Su; Wei Zhou; Wen-Bin Zou; Yang-Yang Qian; Yi-Zhi Chen; Xiao Liu; Jin Yu; Xiao-Nan Yan; An-Jing Zhao; Zhao-Shen Li; Zhuan Liao
Journal:  Dig Dis Sci       Date:  2018-12-17       Impact factor: 3.199

Review 2.  Drug interactions with antacids. Mechanisms and clinical significance.

Authors:  D C Sadowski
Journal:  Drug Saf       Date:  1994-12       Impact factor: 5.606
  2 in total

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