Literature DB >> 5483323

Interference of iron with the absorption of tetracyclines in man.

P J Neuvonen, G Gothoni, R Hackman, K Björksten.   

Abstract

Ferrous sulphate administered together with tetracycline and three of its derivatives-oxytetracycline, methacycline, and doxycycline-was found seriously to impair the absorption of these antibiotics. Thus even small doses of iron taken simultaneously should be avoided during tetracycline treatment.

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Year:  1970        PMID： 5483323      PMCID： PMC1820021          DOI： 10.1136/bmj.4.5734.532

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  4 in total

1.  The effects of various substances on the absorption of tetracycline in rats.

Authors:  E H DEARBORN; J T LITCHFIELD; H J EISNER; J J CORBETT; C W DUNNETT
Journal:  Antibiotic Med Clin Ther (New York)       Date:  1957-10

2.  Avidity of the tetracyclines for the cations of metals.

Authors:  A ALBERT; C W REES
Journal:  Nature       Date:  1956-03-03       Impact factor: 49.962

3.  Inhibition of intestinal iron transport induced by tetracycline.

Authors:  N J Greenberger; R D Ruppert; F E Cuppage
Journal:  Gastroenterology       Date:  1967-10       Impact factor: 22.682

4.  Comparison of in vitro activity and clinical pharmacology of doxycycline with other tetracyclines.

Authors:  J E Rosenblatt; J E Barrett; J L Brodie; W M Kirby
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1966
  4 in total
  32 in total

1.  Inhibition of iron absorption by tetracycline.

Authors:  P J Neuvonen; P J Pentikäinen; G Gothoni
Journal:  Br J Clin Pharmacol       Date:  1975-02       Impact factor: 4.335

Review 2.  Drug interactions that matter. A critical reappraisal.

Authors:  G T McInnes; M J Brodie
Journal:  Drugs       Date:  1988-07       Impact factor: 9.546

3.  Interactions with the absorption of tetracyclines.

Authors:  P J Neuvonen
Journal:  Drugs       Date:  1976       Impact factor: 9.546

Review 4.  Iron supplements: a common cause of drug interactions.

Authors:  N R Campbell; B B Hasinoff
Journal:  Br J Clin Pharmacol       Date:  1991-03       Impact factor: 4.335

Review 5.  Drug metabolism and pharmacokinetics in malutrition.

Authors:  K Krishnaswamy
Journal:  Clin Pharmacokinet       Date:  1978 May-Jun       Impact factor: 6.447

Review 6.  Influence of food and diet on gastrointestinal drug absorption: a review.

Authors:  P G Welling
Journal:  J Pharmacokinet Biopharm       Date:  1977-08

Review 7.  Fluoroquinolones: interaction profile during enteral absorption.

Authors:  K M Deppermann; H Lode
Journal:  Drugs       Date:  1993       Impact factor: 9.546

8.  Ferrous sulfate reduces cimetidine absorption.

Authors:  N R Campbell; B B Hasinoff; J B Meddings; W D Anderson; S Robertson; K Granberg
Journal:  Dig Dis Sci       Date:  1993-05       Impact factor: 3.199

9.  The interaction of warfarin with antacid constituents in the gut.

Authors:  J C McElnay; D W Harron; P F D'Arcy; P S Collier
Journal:  Experientia       Date:  1979-10-15

10.  Effect of zinc sulphate on the absorption of tetracycline and doxycycline in man.

Authors:  O Penttilä; H Hurme; P J Neuvonen
Journal:  Eur J Clin Pharmacol       Date:  1975-12-19       Impact factor: 2.953
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