Literature DB >> 421811

Interaction of digoxin with activated dimethicone and other antacid constituents.

J C McElnay, D W Harron, P F D'Arcy, M R Eagle.   

Abstract

A study was made of the effect of activated dimethicone on the absorption of digoxin in relation to other commonly used antacid constituents using an in vitro experimental model. Dimethicone was found not to affect the absorption of digoxin in relation to aluminium hydroxide, bismuth carbonate, light magnesium carbonate and magnesium trisilicate whose effects on the absorption of digoxin were in agreement with values reported in the literature.

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Year:  1979        PMID： 421811     DOI： 10.1007/bf01917899

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

1.  An in vitro model of drug-metal ion interactions in the gut [proceedings].

Authors:  P F D'Arcy; H A Muhyiddin; J McElnay
Journal:  J Pharm Pharmacol       Date:  1976-12       Impact factor: 3.765

2.  The serum digitalis concentration--does it diagnose digitalis toxicity?

Authors:  J A Ingelfinger; P Goldman
Journal:  N Engl J Med       Date:  1976-04-15       Impact factor: 91.245

3.  Decreased bioavailability of digoxin due to antacids and kaolin-pectin.

Authors:  D D Brown; R P Juhl
Journal:  N Engl J Med       Date:  1976-11-04       Impact factor: 91.245

4.  Effect of silicones on the absorption of anticoagulant drugs.

Authors:  J M Talbot; B W Meade
Journal:  Lancet       Date:  1971-06-19       Impact factor: 79.321

5.  The uptake of digoxin and digitoxin by some antacids.

Authors:  S A Khalil
Journal:  J Pharm Pharmacol       Date:  1974-12       Impact factor: 3.765
  5 in total
  4 in total

1.  The use of buccal partitioning as a model to examine the effects of aluminium hydroxide gel on the absorption of propranolol.

Authors:  J C McElnay; D J Temple
Journal:  Br J Clin Pharmacol       Date:  1982-03       Impact factor: 4.335

2.  The effect of activated dimethicone, other antacid constituents, and kaolin on the absorption of propranolol.

Authors:  J C McElnay; P F D'Arcy; J K Leonard
Journal:  Experientia       Date:  1982-05-15

3.  The interaction of warfarin with antacid constituents in the gut.

Authors:  J C McElnay; D W Harron; P F D'Arcy; P S Collier
Journal:  Experientia       Date:  1979-10-15

Review 4.  Effects of antacids on the clinical pharmacokinetics of drugs. An update.

Authors:  R Gugler; H Allgayer
Journal:  Clin Pharmacokinet       Date:  1990-03       Impact factor: 6.447
  4 in total

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