Literature DB >> 499421

The interaction of warfarin with antacid constituents in the gut.

J C McElnay, D W Harron, P F D'Arcy, P S Collier.   

Abstract

A study was made of the effect of 4 constituents of antacid preparations on the absorption of the coumarin derivate warfarin sodium using an in vitro experimental model. The constituents tested were activated dimethiocone (a silicone) magnesium trisilicate, bismuth carbonate and the adsorbant, kaolin. Slight decreased intestinal absorption was shown by magnesium trisilicate (19%) and bismuth carbonate (7%), the other 2 components showing no effects.

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Year:  1979        PMID： 499421     DOI： 10.1007/bf01964007

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  11 in total

1.  Reduced absorption of aureomycin caused by aluminum hydroxide gel.

Authors:  B A WAISBREN; J S HUECKEL
Journal:  Proc Soc Exp Biol Med       Date:  1950-01

2.  Decreased bioavailability of digoxin due to antacids and kaolin-pectin.

Authors:  D D Brown; R P Juhl
Journal:  N Engl J Med       Date:  1976-11-04       Impact factor: 91.245

3.  Effect of coadministration of aluminum and magnesium hydroxides on absorption of anticoagulants in man.

Authors:  J J Ambre; L J Fischer
Journal:  Clin Pharmacol Ther       Date:  1973 Mar-Apr       Impact factor: 6.875

4.  Effect of silicones on the absorption of anticoagulant drugs.

Authors:  J M Talbot; B W Meade
Journal:  Lancet       Date:  1971-06-19       Impact factor: 79.321

Review 5.  Oral anticoagulants--their interactions.

Authors:  D A Hussar
Journal:  J Am Pharm Assoc       Date:  1970-02       Impact factor: 2.217

6.  Interference of iron with the absorption of tetracyclines in man.

Authors:  P J Neuvonen; G Gothoni; R Hackman; K Björksten
Journal:  Br Med J       Date:  1970-11-28

7.  Interaction of warfarin and nonsystemic gastrointestinal drugs.

Authors:  D S Robinson; D M Benjamin; J J McCormack
Journal:  Clin Pharmacol Ther       Date:  1971 May-Jun       Impact factor: 6.875

8.  The uptake of digoxin and digitoxin by some antacids.

Authors:  S A Khalil
Journal:  J Pharm Pharmacol       Date:  1974-12       Impact factor: 3.765

9.  Rapid fluorometric assay for plasma warfarin.

Authors:  M Corn; R Berberich
Journal:  Clin Chem       Date:  1967-02       Impact factor: 8.327

10.  Interaction of digoxin with activated dimethicone and other antacid constituents.

Authors:  J C McElnay; D W Harron; P F D'Arcy; M R Eagle
Journal:  Experientia       Date:  1979-01-15
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  2 in total

Review 1.  Iron supplements: a common cause of drug interactions.

Authors:  N R Campbell; B B Hasinoff
Journal:  Br J Clin Pharmacol       Date:  1991-03       Impact factor: 4.335

2.  The effect of activated dimethicone, other antacid constituents, and kaolin on the absorption of propranolol.

Authors:  J C McElnay; P F D'Arcy; J K Leonard
Journal:  Experientia       Date:  1982-05-15
  2 in total

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