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Literature DB >> 708022

Pharmacological evaluation of cefaclor in volunteers.

G R Hodges, C Liu, D R Hinthorn, J L Harms, D L Dworzack.

Abstract

The plasma and urine concentrations of cefaclor were measured after oral administration of single and multiple doses to volunteers. Cefaclor was rapidly absorbed, rapidly excreted in the urine, well tolerated without toxicity, and failed to accumulate in the plasma with chronic dosing.

Entities: Chemical Disease

Mesh：

Substances：
Cephalosporins

Year: 1978 PMID： 708022 PMCID： PMC352480 DOI： 10.1128/AAC.14.3.454

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

6 in total

1. In vitro activity of cefaclor, a new orally administered cephalosporin antibiotic.

Authors: J Santoro; M E Levison
Journal: Antimicrob Agents Chemother Date: 1977-09 Impact factor: 5.191

2. Comparative pharmacology of cefaclor and cephalexin.

Authors: O M Korzeniowski; W M Scheld; M A Sande
Journal: Antimicrob Agents Chemother Date: 1977-08 Impact factor: 5.191

3. In vitro susceptibility studies with cefaclor and cephalexin.

Authors: W M Scheld; O M Korzeniowski; M A Sande
Journal: Antimicrob Agents Chemother Date: 1977-08 Impact factor: 5.191

4. Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.

Authors: N J Bill; J A Washington
Journal: Antimicrob Agents Chemother Date: 1977-03 Impact factor: 5.191

5. In vitro activities of five oral cephalosporins against aerobic pathogenic bacteria.

Authors: S Shadomy; G Wagner; M Carver
Journal: Antimicrob Agents Chemother Date: 1977-11 Impact factor: 5.191

6. In vitro studies with cefaclor, a new oral cephalosporin.

Authors: C Sanders
Journal: Antimicrob Agents Chemother Date: 1977-10 Impact factor: 5.191

6 in total

15 in total

1. The effect of four different types of food on the bioavailability of cefaclor.

Authors: S Karim; T Ahmed; T Monif; N Saha; P L Sharma
Journal: Eur J Drug Metab Pharmacokinet Date: 2003 Jul-Sep Impact factor: 2.441

2. Comparative effect of different types of food on the bioavailability of cefaclor extended release tablet.

Authors: B A H Khan; T Ahmed; S Karim; T Monif; N Saha; P L Sharma
Journal: Eur J Drug Metab Pharmacokinet Date: 2004 Apr-Jun Impact factor: 2.441

3. The effect of four different types of diet on the bioavailability of loracarbef.

Authors: A T Bapujee; T Singh; T Ahmed; T Monif; N Saha; P L Sharma
Journal: Eur J Drug Metab Pharmacokinet Date: 2007 Oct-Dec Impact factor: 2.441

4. Phase I study of multiple-dose cefprozil and comparison with cefaclor.

Authors: R H Barbhaiya; U A Shukla; C R Gleason; W C Shyu; R B Wilber; R R Martin; K A Pittman
Journal: Antimicrob Agents Chemother Date: 1990-06 Impact factor: 5.191

5. Comparison of cefprozil and cefaclor pharmacokinetics and tissue penetration.

Authors: R H Barbhaiya; U A Shukla; C R Gleason; W C Shyu; R B Wilber; K A Pittman
Journal: Antimicrob Agents Chemother Date: 1990-06 Impact factor: 5.191

6. Pharmacokinetics of cefuroxime axetil and cefaclor: relationship of concentrations in serum to MICs for common respiratory pathogens.

Authors: N C James; K H Donn; J J Collins; I M Davis; T L Lloyd; R W Hart; J R Powell
Journal: Antimicrob Agents Chemother Date: 1991-09 Impact factor: 5.191