Literature DB >> 6946426

7-Methylguanine in poly(dG-dC).poly(dG-dC) facilitates z-DNA formation.

A Möller, A Nordheim, S R Nichols, A Rich.   

Abstract

Poly(dG-dC).poly(dG-dC) was methylated at the N-7 position of guanine through the use of dimethyl sulfate. The conversion of poly(dG-dC).poly(dG-dC) from B-DNA to the Z-DNA form was followed by measuring both the circular dichroic spectra and changes in the absorbance ratio A295/A260. Increasing methylation steadily decreases the amount of NaCl or MgCl2 that is required to convert the polymer from B-DNA to Z-DNA. At 100% methylation of the guanine residues, the modified polymer is fully converted to Z-DNA in a physiological salt solution. Kinetic experiments show that methylation markedly accelerates the speed of the conversion from B-DNA to Z-DNA in the presence of added salt. These effects may be partly due to the positive charge on guanine that accompanies N-7 methylation.

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Year:  1981        PMID： 6946426      PMCID： PMC320246          DOI： 10.1073/pnas.78.8.4777

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDES.

Authors:  P D LAWLEY; P BROOKES
Journal:  Biochem J       Date:  1963-10       Impact factor: 3.857

Review 2.  The chemical effects of nucleic acid alkylation and their relation to mutagenesis and carcinogenesis.

Authors:  B Singer
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1975

Review 3.  N-nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis.

Authors:  B Singer
Journal:  J Natl Cancer Inst       Date:  1979-06       Impact factor: 13.506

4.  Circular dichroism of mitomycin-DNA complexes. Evidence for a conformational change in DNA.

Authors:  C M Mercado; M Tomasz
Journal:  Biochemistry       Date:  1977-05-03       Impact factor: 3.162

5.  Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).

Authors:  F M Pohl; T M Jovin
Journal:  J Mol Biol       Date:  1972-06-28       Impact factor: 5.469

6.  Polynucleotides. IX. Methylation of nucleic acids, homopolynucleotides and complexes.

Authors:  F Pochon; A M Michelson
Journal:  Biochim Biophys Acta       Date:  1967-11-21

7.  Molecular structure of a left-handed double helical DNA fragment at atomic resolution.

Authors:  A H Wang; G J Quigley; F J Kolpak; J L Crawford; J H van Boom; G van der Marel; A Rich
Journal:  Nature       Date:  1979-12-13       Impact factor: 49.962

8.  The tetramer d(CpGpCpG) crystallizes as a left-handed double helix.

Authors:  J L Crawford; F J Kolpak; A H Wang; G J Quigley; J H van Boom; G van der Marel; A Rich
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

9.  High-salt d(CpGpCpG), a left-handed Z' DNA double helix.

Authors:  H Drew; T Takano; S Tanaka; K Itakura; R E Dickerson
Journal:  Nature       Date:  1980-08-07       Impact factor: 49.962

10.  Left-handed DNA helices.

Authors:  S Arnott; R Chandrasekaran; D L Birdsall; A G Leslie; R L Ratliff
Journal:  Nature       Date:  1980-02-21       Impact factor: 49.962
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  18 in total

1.  Alternating d(G-C)3 and d(C-G)3 hexanucleotides containing 7-deaza-2'-deoxyguanosine or 8-aza-7-deaza-2'-deoxyguanosine in place of dG.

Authors:  F Seela; H Driller
Journal:  Nucleic Acids Res       Date:  1989-02-11       Impact factor: 16.971

2.  Induction of prolactin-deficient variants of GH3 rat pituitary tumor cells by ethyl methanesulfonate: reversion by 5-azacytidine, a DNA methylation inhibitor.

Authors:  R D Ivarie; J A Morris
Journal:  Proc Natl Acad Sci U S A       Date:  1982-05       Impact factor: 11.205

3.  The influence of the purine 2-amino group on DNA conformation and stability. Synthesis and conformational analysis of d[T(2-aminoA)]3.

Authors:  B L Gaffney; L A Marky; R A Jones
Journal:  Nucleic Acids Res       Date:  1982-07-24       Impact factor: 16.971

4.  Statistical mechanics of the B----Z transition of DNA: contribution of diffuse ionic interactions.

Authors:  D M Soumpasis
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

5.  Effect of the B--Z transition in poly(dG-m5dC) . poly(dG-m5dC) on nucleosome formation.

Authors:  J Nickol; M Behe; G Felsenfeld
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

6.  A 1H nOe and CD study of the salt-concentration dependence of the structure of d(G-C).

Authors:  D G Reid; S A Salisbury; D H Williams
Journal:  Nucleic Acids Res       Date:  1983-06-11       Impact factor: 16.971

7.  Interaction of DNA methyltransferase with aminofluorene and N-acetylaminofluorene modified poly(dC-dG).

Authors:  M Ruchirawat; F F Becker; J N Lapeyre
Journal:  Nucleic Acids Res       Date:  1984-04-11       Impact factor: 16.971

8.  Circular dichroism of poly(dG-dC) modified by the carcinogens N-methyl-4-aminoazobenzene or 4-aminobiphenyl.

Authors:  P A Abuaf; F F Kadlubar; D Grunberger
Journal:  Nucleic Acids Res       Date:  1987-09-11       Impact factor: 16.971

9.  NMR, CD and IR spectroscopies of a tridecanucleotide containing a no-base residue: coexistence of B and Z conformations.

Authors:  S Pochet; T Huynh-Dinh; J M Neumann; S Tran-Dinh; S Adam; J Taboury; E Taillandier; J Igolen
Journal:  Nucleic Acids Res       Date:  1986-01-24       Impact factor: 16.971

10.  Ethylation of poly(dC-dG).poly(dC-dG) by ethyl methanesulfonate stimulates the activity of mammalian DNA methyltransferase in vitro.

Authors:  I K Farrance; R Ivarie
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205
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