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Literature DB >> 6885160

Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin.

Abstract

The in vitro effects of pneumolysin, a sulfhydryl-activated toxin produced by Streptococcus pneumoniae, on various functions of human polymorphonuclear leukocytes (PMNLs) was investigated. Treatment of PMNLs with highly purified toxin significantly inhibited respiratory burst (in response to stimulation), ability to kill opsonized pneumococci, chemotaxis, and random migration. These inhibitions were observed at very low toxin doses (less than or equal to 1 hemolytic unit (2 ng) per 10(6) PMNLs), which had no effect on PMNL viability. These results suggest that pneumolysin could function in pathogenicity by interfering with the ability of PMNLs to migrate toward and kill pneumococci.

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Year: 1983 PMID： 6885160 PMCID： PMC264628 DOI： 10.1128/iai.41.3.1212-1216.1983

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

12 in total

1. Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes.

Authors: R D Nelson; P G Quie; R L Simmons
Journal: J Immunol Date: 1975-12 Impact factor: 5.422

2. Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae.

Authors: J C Paton; R A Lock; D J Hansman
Journal: Infect Immun Date: 1983-05 Impact factor: 3.441

3. Separation of mononuclear and polymorphonuclear leucocytes from human blood by the one-step Hypaque-Ficoll method is dependent on blood column height.

Authors: A Ferrante; Y H Thong
Journal: J Immunol Methods Date: 1982 Impact factor: 2.303

Review 4. The microbicidal mechanisms of human neutrophils and eosinophils.

Authors: R K Root; M S Cohen
Journal: Rev Infect Dis Date: 1981 May-Jun

5. Binding of cholesterol by sulfhydryl-activated cytolysins.

Authors: M K Johnson; C Geoffroy; J E Alouf
Journal: Infect Immun Date: 1980-01 Impact factor: 3.441

6. Activation of human neutrophil metabolism by streptolysin O.

Authors: B R Andersen; J L Duncan
Journal: J Infect Dis Date: 1980-05 Impact factor: 5.226

7. Effects of pneumolysin on human polymorphonuclear leukocytes and platelets.

Authors: M K Johnson; D Boese-Marrazzo; W A Pierce
Journal: Infect Immun Date: 1981-10 Impact factor: 3.441

8. Early decay of human neutrophil chemotactic responsiveness following isolation from peripheral blood.

Authors: A Ferrante; L J Beard; Y H Thong
Journal: Clin Exp Immunol Date: 1980-02 Impact factor: 4.330

9. Improved method for neutrophil hexose-monophosphate shunt assay using serum.

Authors: Y H Thong; V O Rencis
Journal: J Immunol Methods Date: 1980 Impact factor: 2.303

Review 10. The host response to invasion by Streptococcus pneumoniae: protection and the pathogenesis to tissue damage.

Authors: R B Johnston
Journal: Rev Infect Dis Date: 1981 Mar-Apr

76 in total

1. An Arcanobacterium (Actinomyces) pyogenes mutant deficient in production of the pore-forming cytolysin pyolysin has reduced virulence.

Authors: B H Jost; J G Songer; S J Billington
Journal: Infect Immun Date: 1999-04 Impact factor: 3.441

2. Effect on polymorphonuclear cell function of a human-specific cytotoxin, intermedilysin, expressed by Streptococcus intermedius.

Authors: M G Macey; R A Whiley; L Miller; H Nagamune
Journal: Infect Immun Date: 2001-10 Impact factor: 3.441

3. Induction of gamma interferon and nitric oxide by truncated pneumolysin that lacks pore-forming activity.

Authors: Hisashi Baba; Ikuo Kawamura; Chikara Kohda; Takamasa Nomura; Yutaka Ito; Terumi Kimoto; Isao Watanabe; Satoshi Ichiyama; Masao Mitsuyama
Journal: Infect Immun Date: 2002-01 Impact factor: 3.441

4. CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection.

Authors: Aras Kadioglu; William Coward; M Joseph Colston; Colin R A Hewitt; Peter W Andrew
Journal: Infect Immun Date: 2004-05 Impact factor: 3.441

5. Host cellular immune response to pneumococcal lung infection in mice.

Authors: A Kadioglu; N A Gingles; K Grattan; A Kerr; T J Mitchell; P W Andrew
Journal: Infect Immun Date: 2000-02 Impact factor: 3.441

6. Contributions to protection from Streptococcus pneumoniae infection using the monovalent recombinant protein vaccine candidates PcpA, PhtD, and PlyD1 in an infant murine model during challenge.

Authors: David Verhoeven; Sheldon Perry; Michael E Pichichero
Journal: Clin Vaccine Immunol Date: 2014-05-21

10. Human neutrophils require activation by mononuclear leucocyte conditioned medium to kill the pathogenic free-living amoeba, Naegleria fowleri.

Authors: A Ferrante; T J Mocatta
Journal: Clin Exp Immunol Date: 1984-06 Impact factor: 4.330