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Literature DB >> 7298179

Effects of pneumolysin on human polymorphonuclear leukocytes and platelets.

M K Johnson, D Boese-Marrazzo, W A Pierce.

Abstract

Pneumolysin was bound by human polymorphonuclear leukocytes in a reaction which occurred very rapidly at 0 degrees C. Low concentrations of pneumolysin were found to stimulate leukocyte migration and lysosomal enzyme secretion. At increasing lysin levels, inhibition of spontaneous migration and chemotaxis, cell death, and lysis were observed. Pneumolysin was also found to lyse platelets and to activate serum to become chemotactic.

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Year: 1981 PMID： 7298179 PMCID： PMC350839 DOI： 10.1128/iai.34.1.171-176.1981

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

10 in total

1. Inhibition of leukocyte locomotion and chemotaxis by lipid-specific bacterial toxins.

Authors: P C Wilkinson
Journal: Nature Date: 1975-06-05 Impact factor: 49.962

2. ELECTRON MICROSCOPE STUDY OF THE DEGRANULATION OF POLYMORPHONUCLEAR LEUKOCYTES FOLLOWING TREATMENT WITH STREPTOLYSIN.

Authors: D ZUCKER-FRANKLIN
Journal: Am J Pathol Date: 1965-09 Impact factor: 4.307

3. The role of cytolysin in pneumococcal ocular infection.

Authors: M K Johnson; J H Allen
Journal: Am J Ophthalmol Date: 1975-09 Impact factor: 5.258

4. Suppression of chemotatic activity of human neutrophils by streptolysin O.

Authors: B R Andersen; D E Van Epps
Journal: J Infect Dis Date: 1972-04 Impact factor: 5.226

5. Bacterial factors chemotactic for polymorphonuclear leukocytes.

Authors: P A Ward; I H Lepow; L J Newman
Journal: Am J Pathol Date: 1968-04 Impact factor: 4.307

6. Biochemical and ultrastructural study of the disruption of blood platelets by streptolysin O.

Authors: J M Launay; J E Alouf
Journal: Biochim Biophys Acta Date: 1979-09-21

7. Binding of cholesterol by sulfhydryl-activated cytolysins.

Authors: M K Johnson; C Geoffroy; J E Alouf
Journal: Infect Immun Date: 1980-01 Impact factor: 3.441

8. The secretion of protein by the polymorphonuclear leucocyte treated with streptolysin O.

Authors: A M Woodin; A A Wieneke
Journal: Exp Cell Res Date: 1966-09 Impact factor: 3.905

9. Properties of purified pneumococcal hemolysin.

Authors: M K Johnson
Journal: Infect Immun Date: 1972-11 Impact factor: 3.441

10. STUDIES ON LYSOSOMES. III. THE EFFECTS OF STREPTOLYSINS O AND S ON THE RELEASE OF ACID HYDROLASES FROM A GRANULAR FRACTION OF RABBIT LIVER.

Authors: G WEISSMANN; H KEISER; A W BERNHEIMER
Journal: J Exp Med Date: 1963-08-01 Impact factor: 14.307

10 in total

29 in total

1. Effect on polymorphonuclear cell function of a human-specific cytotoxin, intermedilysin, expressed by Streptococcus intermedius.

Authors: M G Macey; R A Whiley; L Miller; H Nagamune
Journal: Infect Immun Date: 2001-10 Impact factor: 3.441

2. Pneumolysin-induced complement depletion during experimental pneumococcal bacteremia.

Authors: R B Alcantara; L C Preheim; M J Gentry-Nielsen
Journal: Infect Immun Date: 2001-06 Impact factor: 3.441

3. Effect of Streptococcus pneumoniae on human respiratory epithelium in vitro.

Authors: C Steinfort; R Wilson; T Mitchell; C Feldman; A Rutman; H Todd; D Sykes; J Walker; K Saunders; P W Andrew
Journal: Infect Immun Date: 1989-07 Impact factor: 3.441

4. Production and purification of Streptococcus pneumoniae hemolysin (pneumolysin).

Authors: K Kanclerski; R Möllby
Journal: J Clin Microbiol Date: 1987-02 Impact factor: 5.948

5. Modulation of granulocyte functions by bacterial exotoxin and endotoxins.

Authors: K D Bremm; W König; M Thelestam; J E Alouf
Journal: Immunology Date: 1987-11 Impact factor: 7.397

6. The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease.

Authors: Amit Srivastava; Philipp Henneke; Alberto Visintin; Sarah C Morse; Victoria Martin; Claire Watkins; James C Paton; Michael R Wessels; Douglas T Golenbock; Richard Malley
Journal: Infect Immun Date: 2005-10 Impact factor: 3.441

7. Characterization of a recombinant pneumolysin and its use as a protein carrier for pneumococcal type 18C conjugate vaccines.

Authors: J Kuo; M Douglas; H K Ree; A A Lindberg
Journal: Infect Immun Date: 1995-07 Impact factor: 3.441