Literature DB >> 8675351

Neutralizing monoclonal antibodies against listeriolysin: mapping of epitopes involved in pore formation.

A Darji1, K Niebuhr, M Hense, J Wehland, T Chakraborty, S Weiss.   

Abstract

Six different mouse monoclonal antibodies (MAbs) and a specific rabbit polygonal antibody were raised against listeriolysin. Four of the MAbs also recognized seeligeriolysin, and five cross-reacted with ivanolysin. The hemolytic activity could be neutralized by the polygonal antibody as well as by five of the MAbs. None of the neutralizing antibodies interfered with the binding of listeriolysin to the cellular membrane. The epitopes recognized by the MAbs were localized by using overlapping synthetic peptides between positions 59 and 279, a region hitherto not implicated in mediating hemolytic activity.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8675351      PMCID： PMC174080          DOI： 10.1128/iai.64.6.2356-2358.1996

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  20 in total

1.  Nucleotide sequence of the streptolysin O (SLO) gene: structural homologies between SLO and other membrane-damaging, thiol-activated toxins.

Authors:  M A Kehoe; L Miller; J A Walker; G J Boulnois
Journal:  Infect Immun       Date:  1987-12       Impact factor: 3.441

2.  Suppression of chemotatic activity of human neutrophils by streptolysin O.

Authors:  B R Andersen; D E Van Epps
Journal:  J Infect Dis       Date:  1972-04       Impact factor: 5.226

3.  Molecular cloning, characterization, and complete nucleotide sequence of the gene for pneumolysin, the sulfhydryl-activated toxin of Streptococcus pneumoniae.

Authors:  J A Walker; R L Allen; P Falmagne; M K Johnson; G J Boulnois
Journal:  Infect Immun       Date:  1987-05       Impact factor: 3.441

4.  Ia-transfected L-cell fibroblasts present a lysozyme peptide but not the native protein to lysozyme-specific T cells.

Authors:  N Shastri; B Malissen; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

5.  Nucleotide sequence of the gene for perfringolysin O (theta-toxin) from Clostridium perfringens: significant homology with the genes for streptolysin O and pneumolysin.

Authors:  R K Tweten
Journal:  Infect Immun       Date:  1988-12       Impact factor: 3.441

6.  Mechanism of membrane damage by streptolysin-O.

Authors:  S Bhakdi; J Tranum-Jensen; A Sziegoleit
Journal:  Infect Immun       Date:  1985-01       Impact factor: 3.441

7.  Detection of listeriolysin, the thiol-dependent hemolysin in Listeria monocytogenes, Listeria ivanovii, and Listeria seeligeri.

Authors:  M Leimeister-Wächter; T Chakraborty
Journal:  Infect Immun       Date:  1989-08       Impact factor: 3.441

8.  Detection of a prfA-independent promoter responsible for listeriolysin gene expression in mutant Listeria monocytogenes strains lacking the PrfA regulator.

Authors:  E Domann; J Wehland; K Niebuhr; C Haffner; M Leimeister-Wächter; T Chakraborty
Journal:  Infect Immun       Date:  1993-07       Impact factor: 3.441

9.  Expression in Escherichia coli and sequence analysis of the listeriolysin O determinant of Listeria monocytogenes.

Authors:  J Mengaud; M F Vicente; J Chenevert; J M Pereira; C Geoffroy; B Gicquel-Sanzey; F Baquero; J C Perez-Diaz; P Cossart
Journal:  Infect Immun       Date:  1988-04       Impact factor: 3.441

10.  Effects of Listeria monocytogenes and Yersinia enterocolitica on cytokine gene expression and release from human polymorphonuclear granulocytes and epithelial (HEp-2) cells.

Authors:  R Arnold; J Scheffer; B König; W König
Journal:  Infect Immun       Date:  1993-06       Impact factor: 3.441
View more
  9 in total

1.  Dissociated linkage of cytokine-inducing activity and cytotoxicity to different domains of listeriolysin O from Listeria monocytogenes.

Authors:  Chikara Kohda; Ikuo Kawamura; Hisashi Baba; Takamasa Nomura; Yutaka Ito; Terumi Kimoto; Isao Watanabe; Masao Mitsuyama
Journal:  Infect Immun       Date:  2002-03       Impact factor: 3.441

Review 2.  Listeria pathogenesis and molecular virulence determinants.

Authors:  J A Vázquez-Boland; M Kuhn; P Berche; T Chakraborty; G Domínguez-Bernal; W Goebel; B González-Zorn; J Wehland; J Kreft
Journal:  Clin Microbiol Rev       Date:  2001-07       Impact factor: 26.132

3.  Novel bacterial artificial chromosome vector pUvBBAC for use in studies of the functional genomics of Listeria spp.

Authors:  Torsten Hain; Sonja Otten; Ulrich von Both; Som S Chatterjee; Ulrike Technow; André Billion; Rohit Ghai; Walid Mohamed; Eugen Domann; Trinad Chakraborty
Journal:  Appl Environ Microbiol       Date:  2008-01-25       Impact factor: 4.792

4.  A hybrid sub-lineage of Listeria monocytogenes comprising hypervirulent isolates.

Authors:  Yuelan Yin; Hao Yao; Swapnil Doijad; Suwei Kong; Yang Shen; Xuexue Cai; Weijun Tan; Yuting Wang; Youwei Feng; Zhiting Ling; Guoliang Wang; Yachen Hu; Kai Lian; Xinyu Sun; Yuliang Liu; Chuanbin Wang; Kuhua Jiao; Guoping Liu; Ruilong Song; Xiang Chen; Zhiming Pan; Martin J Loessner; Trinad Chakraborty; Xin'an Jiao
Journal:  Nat Commun       Date:  2019-09-30       Impact factor: 14.919

5.  Targeted amino acid substitutions impair streptolysin O toxicity and group A Streptococcus virulence.

Authors:  Emiliano Chiarot; Cristina Faralla; Nico Chiappini; Giovanna Tuscano; Fabiana Falugi; Gabriella Gambellini; Annarita Taddei; Sabrina Capo; Elena Cartocci; Daniele Veggi; Alessia Corrado; Simona Mangiavacchi; Simona Tavarini; Maria Scarselli; Robert Janulczyk; Guido Grandi; Immaculada Margarit; Giuliano Bensi
Journal:  MBio       Date:  2013-01-08       Impact factor: 7.867

Review 6.  Mini-review: novel therapeutic strategies to blunt actions of pneumolysin in the lungs.

Authors:  Rudolf Lucas; Istvan Czikora; Supriya Sridhar; Evgeny Zemskov; Boris Gorshkov; Umapathy Siddaramappa; Aluya Oseghale; Jonathan Lawson; Alexander Verin; Ferenc G Rick; Norman L Block; Helena Pillich; Maritza Romero; Martin Leustik; Andrew V Schally; Trinad Chakraborty
Journal:  Toxins (Basel)       Date:  2013-07-15       Impact factor: 4.546

7.  Prediction of B-Cell Epitopes in Listeriolysin O, a Cholesterol Dependent Cytolysin Secreted by Listeria monocytogenes.

Authors:  Morris S Jones; J Mark Carter
Journal:  Adv Bioinformatics       Date:  2014-01-02

Review 8.  Inhibition of Pore-Forming Proteins.

Authors:  Neža Omersa; Marjetka Podobnik; Gregor Anderluh
Journal:  Toxins (Basel)       Date:  2019-09-19       Impact factor: 4.546

9.  Mapping of Recognition Sites of Monoclonal Antibodies Responsible for the Inhibition of Pneumolysin Functional Activity.

Authors:  Indre Kucinskaite-Kodze; Martynas Simanavicius; Justas Dapkunas; Milda Pleckaityte; Aurelija Zvirbliene
Journal:  Biomolecules       Date:  2020-07-08
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.