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Literature DB >> 6479148

Two non-allelic human interferon alpha genes with identical coding regions.

Abstract

A hitherto undescribed human interferon-alpha (IFN-alpha) gene, IFN-alpha 13, has been isolated and characterized. Its entire coding sequence is completely identical with that of IFN-alpha 1; the 5' and 3' non-coding regions differ by 4.5% and 3.8%, respectively. As the two genes are not allelic, we conclude that the similarity is due to a very recent gene conversion event. Both genes are expressed in virus-induced leukocytes.

Entities: Chemical

Mesh：

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Year: 1984 PMID： 6479148 PMCID： PMC557600 DOI： 10.1002/j.1460-2075.1984.tb02050.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

34 in total

1. Molecular cloning and characterization of the human beta-like globin gene cluster.

Authors: E F Fritsch; R M Lawn; T Maniatis
Journal: Cell Date: 1980-04 Impact factor: 41.582

2. The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha.

Authors: S Nagata; N Mantei; C Weissmann
Journal: Nature Date: 1980-10-02 Impact factor: 49.962

3. The nucleotide sequence of a cloned human leukocyte interferon cDNA.

Authors: N Mantei; M Schwarzstein; M Streuli; S Panem; S Nagata; C Weissmann
Journal: Gene Date: 1980-06 Impact factor: 3.688

4. The structure of eight distinct cloned human leukocyte interferon cDNAs.

Authors: D V Goeddel; D W Leung; T J Dull; M Gross; R M Lawn; R McCandliss; P H Seeburg; A Ullrich; E Yelverton; P W Gray
Journal: Nature Date: 1981-03-05 Impact factor: 49.962

5. Structure, organization and evolution of developmentally regulated chorion genes in a silkmoth.

Authors: C W Jones; F C Kafatos
Journal: Cell Date: 1980-12 Impact factor: 41.582

6. The evolution of genes: the chicken preproinsulin gene.

Authors: F Perler; A Efstratiadis; P Lomedico; W Gilbert; R Kolodner; J Dodgson
Journal: Cell Date: 1980-06 Impact factor: 41.582

7. Intrachromosomal gene conversion in yeast.

Authors: H L Klein; T D Petes
Journal: Nature Date: 1981-01-15 Impact factor: 49.962

8. Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes.

Authors: J L Slightom; A E Blechl; O Smithies
Journal: Cell Date: 1980-10 Impact factor: 41.582

9. Physical mapping of the globin gene deletion in hereditary persistence of foetal haemoglobin (HPFH).

Authors: R Bernards; R A Flavell
Journal: Nucleic Acids Res Date: 1980-04-11 Impact factor: 16.971

10. Homology and concerted evolution at the alpha 1 and alpha 2 loci of human alpha-globin.

Authors: S A Liebhaber; M Goossens; Y W Kan
Journal: Nature Date: 1981-03-05 Impact factor: 49.962

11 in total

1. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.

Authors: T A Nyman; H Tölö; J Parkkinen; N Kalkkinen
Journal: Biochem J Date: 1998-01-15 Impact factor: 3.857

2. Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides.

Authors: D J Capon; H M Shepard; D V Goeddel
Journal: Mol Cell Biol Date: 1985-04 Impact factor: 4.272

Two non-allelic human interferon alpha genes with identical coding regions.

1. Molecular cloning and characterization of the human beta-like globin gene cluster.

2. The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha.

3. The nucleotide sequence of a cloned human leukocyte interferon cDNA.

4. The structure of eight distinct cloned human leukocyte interferon cDNAs.

5. Structure, organization and evolution of developmentally regulated chorion genes in a silkmoth.

6. The evolution of genes: the chicken preproinsulin gene.

7. Intrachromosomal gene conversion in yeast.

8. Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes.

9. Physical mapping of the globin gene deletion in hereditary persistence of foetal haemoglobin (HPFH).

10. Homology and concerted evolution at the alpha 1 and alpha 2 loci of human alpha-globin.

1. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.

2. Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides.

3. Isolation of tobacco SSU genes: characterization of a transcriptionally active pseudogene.

4. Organization, structure and expression of murine interferon alpha genes.

5. Polymorphism in the interferon-alpha gene family.

6. A novel class of human type I interferons.

7. Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.

8. Evolution of the interferon alpha gene family in eutherian mammals.

9. The evolution of the type I interferon gene family in mammals.

10. Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals.