Complement loci of the HLA complex. Studies on families with intra-HLA crossovers and haplotype associations.

We report genetic studies of families with defined crossovers in the HLA complex. Haplotypic associations between the different alleles have been analyzed. The object of the studies has been to determine the precise location of complement loci on the HLA complex on chromosome 6. Based on direct observation of recombinations and on indirect evidence from haplotypes, we postulate that the C4 and Bf loci are located between the HLA-B and -D regions and probably closer to the former. Available information also points towards the same localization for the C2 locus.